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Long-term follow-up in patients with brain arteriovenous malformation based on the Quality of Life Scale and socioeconomic status

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Abstract

Objective

Intracranial haemorrhage (ICH) is associated with permanent neurological disability resulting in deterioration of the quality of life (QoL). Our study assesses QoL in patients with ruptured arteriovenous malformation (AVM) in long-term follow-up at least five years after ICH and compares their QoL with the QoL of patient with non-ruptured AVM.

Methods

Using the Quality of Life Scale (QOLS), the Patient Health Questionnaire (PHQ-9) for depressive symptoms, and the socioeconomic status (SES), a prospective assessment was performed. The modified Rankin Scale (mRS) was assessed for outcome.

Results

Of 73 patients, 42 (57.5%) had ruptured (group 1) and 31 (42.5%) a non-ruptured AVM (group 2). Mean follow-up time was 8.6 ± 3.9 years (8.5 ± 4.2 years in group 1 and 8.9 ± 3.7 years in group 2). Favourable outcome (mRS 0–1) was assessed in 60 (83.3%) and unfavourable in 12 (16.7%) patients. Thirty-one of 42 patients (73.8%) in group 1 and 29 of 30 patients in group 2 (96.7%) had favourable outcomes. Mean QOLS was 85.6 ± 14.1 (group 1 86.1 ± 15.9, group 2 84.9 ± 11.4). Patients in group 1 did not show a significant difference in QoL compared to patients in group 2 (p = 0.23). Additional analyses in group 2 (rho =  − 0.73; p < 0.01) and in untreated AVM patients (rho =  − 0.81; p < 0.01) showed a strong correlation between QOLS and PHQ-9.

Conclusion

Long-term follow-up showed no difference in the QoL between patients with and without ICH caused by brain AVM. Outcome- and QoL-scores were high in both groups. Further studies are necessary to evaluate depression and anxiety symptoms in patients with AVM.

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Availability of data and materials

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Code availability

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Acknowledgements

The authors thank Marina Heibel for her support during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, Goethe University Hospital Frankfurt, Schleusenweg 16, 60528, Frankfurt a.M., Germany

    Lina Benhassine, Sae-Yeon Won, Gerhard Marquardt, Markus Czabanka, Christian A. Senft, Volker Seifert & Nazife Dinc

  2. Department of Neurosurgery, University Hospital Rostock, Rostock, Germany

    Sae-Yeon Won

  3. Department of Biostatistics, Goethe University Hospital Frankfurt, Frankfurt, Germany

    Natalie Filmann & Ümniye Balaban

  4. Department of Neurosurgery, Friedrich Schiller University Hospital Jena, Jena, Germany

    Marcel A. Kamp, Christian A. Senft & Nazife Dinc

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  1. Lina Benhassine
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Lina Benhassine. The first draft of the manuscript was written by Lina Benhassine, and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

LB — concept development, data collection, provided and cared for study patients, data interpretation as well as the below-listed contributions.

ND — concept development and substantial involvement in the development of the draft manuscript.

SYW, NF, GM, ÜB — contributed important intellectual content, served as scientific advisers.

GM, VS, MK, SYW, CS, MC, MAK — critical review of the study proposal and final approval.

All the authors agreed to be accountable for all aspects of the work for accuracy and are committed to the integrity of the final product.

Corresponding author

Correspondence to Lina Benhassine.

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Ethics approval

All procedures performed in studies involving human participants were following the ethical standards of the institutional committee (University Hospital Frankfurt am Main) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study protocol was reviewed and approved by the ethics committee at University Hospital Frankfurt am Main, approval number 136/19.

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Written informed consent for participation was obtained from all study participants before their inclusion in the study.

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Written informed consent for publication was obtained from all study participants before their inclusion in the study.

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The authors declare no competing interests.

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The study was registered prospectively on 7 July 2019, trial registration number: DRKS00017409.

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Benhassine, L., Won, SY., Filmann, N. et al. Long-term follow-up in patients with brain arteriovenous malformation based on the Quality of Life Scale and socioeconomic status. Neurosurg Rev 45, 3281–3290 (2022). https://doi.org/10.1007/s10143-022-01847-8

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