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Biomarkers for traumatic brain injury: a short review

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Abstract

Cellular response to TBI is a mixture of excitotoxicity, neuroinflammation, and cell death. Biomarkers that can track these lesions and inflammatory processes are being explored for their potential to provide objective measures in the evaluation of TBI, from prehospital care to rehabilitation. By understanding the pathways involved, we could be able to improve diagnostic accuracy, guide management, and prevent long-term disability. We listed some of the recent advances in this translational, intriguing, fast-growing field. Although the knowledge gaps are still significant, some markers are showing promising results and could be helping patients in the near future.

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Funding

This work had support from the CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico- Brazil.

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Authors and Affiliations

  1. Division of Neurosurgery, University of São Paulo, São Paulo, Brazil

    Marcela Usberti Gutierre, João Paulo Mota Telles, Nícollas Nunes Rabelo, Manoel Jacobsen Teixeira & Eberval Gadelha Figueiredo

  2. Department of Neurological Surgery, State University of Ponta Grossa, Ponta Grossa, Brazil

    Leonardo Christiaan Welling

  3. Rua Eneas Aguiar, 255, 05403-010, São Paulo, Brazil

    Eberval Gadelha Figueiredo

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  1. Marcela Usberti Gutierre
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Gutierre, M.U., Telles, J.P.M., Welling, L.C. et al. Biomarkers for traumatic brain injury: a short review. Neurosurg Rev 44, 2091–2097 (2021). https://doi.org/10.1007/s10143-020-01421-0

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