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Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis

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Abstract

The aneurysmal subarachnoid hemorrhage is a major public health problem described as a sudden drastic event with no warning symptoms and high morbidity and mortality rates. The role of the endothelial isoform of nitric oxide synthase gene polymorphism in intracranial aneurysms (IAs) is still a matter of controversy with divergent findings among European, American, and Asian populations. Our study purposed to test the association between intracranial aneurysms formation and nitric oxide gene polymorphisms through a systematic review and meta-analysis. Systematic search on Medline, Lilacs, and EMBASE was performed. The primary search resulted in 139 papers, out of which 9 met our inclusion criteria after a full text analysis. The dominant T786C model found a significant association with IA (OR 1.22, 95 % CI 1.04–1.44, p = 0.01), so did studies of the recessive T786C model (OR 0.37, 95 % CI 0.30–0.45, p < 0.0001) but with opposite effect. Our findings support the presence of the T786C polymorphism as a predictor for the development of intracranial aneurysm in the cerebral vascular system. More studies are necessary in order to elucidate the pathways of the endothelial nitric oxide synthase (eNOS) in cerebrovascular diseases and in defining how different allelic combinations of the eNOS gene single-nucleotide polymorphism (SNP) could favor this pathological process.

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Authors and Affiliations

  1. Department of Neurosurgery, Universidade Federal do Pará, Rua Bernal do Couto, 106; Apt 1202, 66055-080, Belem, PA, Brazil

    Eric Homero Albuquerque Paschoal

  2. Department of Neurosurgery, Universidade de São Paulo, São Paulo, SP, Brazil

    Eric Homero Albuquerque Paschoal, Fernando Mendes Paschoal Junior, Manoel Jacobsen Teixeira & Edson Bor-Seng-Shu

  3. Department of Neurosurgery, Universidade do Estado do Pará, Belém, PA, Brazil

    Vitor Nagai Yamaki & Glaucia Suzanna Jong-A-Liem

  4. Department of Surgery, Universidade do Estado do Pará, Belém, PA, Brazil

    Renan Kleber Costa Teixeira

  5. Department of Neurology, Universidade Federal do Pará, Belem, PA, Brazil

    Fernando Mendes Paschoal Junior

  6. Department of Genetics, Universidade Federal do Pará, Belem, PA, Brazil

    Elizabeth Sumi Yamada & Ândrea Ribeiro-dos-Santos

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  1. Eric Homero Albuquerque Paschoal
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  2. Vitor Nagai Yamaki
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Correspondence to Eric Homero Albuquerque Paschoal.

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eNOS and Intracranial Aneurysms

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Paschoal, E.H.A., Yamaki, V.N., Teixeira, R.K.C. et al. Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis. Neurosurg Rev 41, 87–94 (2018). https://doi.org/10.1007/s10143-016-0761-4

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  • DOI: https://doi.org/10.1007/s10143-016-0761-4

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