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Advances in neuroimaging: management of partial epileptic syndromes

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Abstract

Structural and functional neuroimaging studies are essential in the evaluation of individuals with partial epilepsy syndromes. Magnetic resonance imaging (MRI) is important to delineate structural abnormalities underlying seizure disorders, commonly including hippocampal sclerosis or cortical dysplasias. Identification of a structural lesion is often a reliable indicator of the site of seizure onset. Magnetic resonance spectroscopy (MRS) allows us to investigate cerebral metabolites and some neurotransmitters. Reduction in various metabolite concentrations has proven to be prognostically valuable when no structural abnormality is identified. Positron emission tomography (PET) using deoxyglucose demonstrates areas of reduced glucose metabolism, which are the hallmark of epileptogenic zones and usually extend beyond the underlying anatomical region. It is useful in temporal lobe epilepsy for lateralization; however, results in extratemporal lobe epilepsy have been less favorable. More promising is the use of benzodiazepine receptor ligands, which are reduced in the epileptogenic zone in a more restricted distribution. This appears to be helpful in the localization of extratemporal seizure foci. Peri-ictal single photon emission computed tomography measures increased blood flow during the ictal event and is beneficial in patients with normal MRI studies to determine lateralization and localization of the ictal onset zone. All imaging modalities should be correlated with clinical and neurophysiological data.

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References

  1. Aronica E, Leenstra S, van Veelen CW, van Rijen PC, Hulsebos TJ, Tersmette AC, Yankaya B, Troost D (2001) Glioneuronal tumors and medically intractable epilepsy: a clinical study with long-term follow-up of seizure outcome after surgery. Epilepsy Res 43:179–191

    Google Scholar 

  2. Barkovich AJ, Kuzniecky RI, Dobyns WB (2001) Radiologic classification of malformations of cortical development. Curr Opin Neurol 14:145–149

    Article  CAS  PubMed  Google Scholar 

  3. Berkovic SF (2000) SPECT: neurobiology of periictal blood flow alterations. Adv Neurol 83:33–39

    CAS  PubMed  Google Scholar 

  4. Berkovic SF, Andermann F, Olivier A, Ethier R, Melanson D, Robitaille Y, Kuzniecky R, Peters T, Feindel W (1991) Hippocampal sclerosis in temporal lobe epilepsy demonstrated by magnetic resonance imaging. Ann Neurol 29:175–182

    CAS  PubMed  Google Scholar 

  5. Bernardi S, Trimble MR, Frackowiak RS, Wise RJ, Jones T (1983) An interictal study of partial epilepsy using positron emission tomography and the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiatry 46:473–477

    CAS  PubMed  Google Scholar 

  6. Brinkmann BH, O'Brien TJ, Webster DB, Mullan BP, Robins PD, Robb RA (2000) Voxel significance mapping using local image variances in subtraction ictal SPET. Nucl Med Commun 21:545–551

    Article  CAS  PubMed  Google Scholar 

  7. Britton JW, Cascino GD, Sharbrough FW, Kelly PJ (1994) Low-grade glial neoplasms and intractable partial epilepsy: efficacy of surgical treatment. Epilepsia 35:1130–1135

    CAS  PubMed  Google Scholar 

  8. Bronen RA, Cheung G, Charles JT, Kim JH, Spencer DD, Spencer SS, Sze G, McCarthy G (1991) Imaging findings in hippocampal sclerosis: correlation with pathology. AJNR Am J Neuroradiol 12:933–940

    CAS  PubMed  Google Scholar 

  9. Carpio A, Escobar A, Hauser WA (1998) Cysticercosis and epilepsy: a critical review. Epilepsia 39:1025–1040

    CAS  PubMed  Google Scholar 

  10. Carreno M, Luders HO (2000) General principles of presurgical evaluation. In: Luders HO, Comair Y (eds) Epilepsy surgery, 2nd edn. Lippincott, Philadelphia, pp 185–199

  11. Cascino GD (1990) Epilepsy and brain tumors: implications for treatment. Epilepsia 31 [Suppl 3]:S37–S44

  12. Cascino GD (1994) Commentary: how has neuroimaging improved patient care? Epilepsia 35 [Suppl 6]:S103–S107

  13. Cascino GD (1995) Structural neuroimaging in partial epilepsy. Magnetic resonance imaging. Neurosurg Clin N Am 6:455–464

    CAS  PubMed  Google Scholar 

  14. Cascino GD (2001) Advances in neuroimaging: surgical localization. Epilepsia 42:3–12

    Article  CAS  Google Scholar 

  15. Cascino GD, Jack CR Jr, Parisi JE, Sharbrough FW, Hirschorn KA, Meyer FB, Marsh WR, O'Brien PC (1991) Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: pathological correlations. Ann Neurol 30:31–36

    Google Scholar 

  16. Cascino GD, Jack CR Jr, Parisi JE, Marsh WR, Kelly PJ, Sharbrough FW, Hirschorn KA, Trenerry MR (1992) MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. Epilepsy Res 11:51–59

    CAS  PubMed  Google Scholar 

  17. Cascino GD, Jack CR Jr, Parisi JE, Sharbrough FW, Schreiber CP, Kelly PJ, Trenerry MR (1993) Operative strategy in patients with MRI-identified dual pathology and temporal lobe epilepsy. Epilepsy Res 14:175–182

    CAS  PubMed  Google Scholar 

  18. Cascino GD, Sharbrough FW, Trenerry MR, Marsh WR, Kelly PJ, So E (1994) Extratemporal cortical resections and lesionectomies for partial epilepsy: complications of surgical treatment. Epilepsia 35:1085–1090

    CAS  PubMed  Google Scholar 

  19. Cascino GD, Trenerry MR, So EL, Sharbrough FW, Shin C, Lagerlund TD, Zupanc ML, Jack CR Jr (1996) Routine EEG and temporal lobe epilepsy: relation to long-term EEG monitoring, quantitative MRI, and operative outcome. Epilepsia 37:651–656

    CAS  PubMed  Google Scholar 

  20. Cendes F, Andermann F, Dubeau F, Gloor P, Evans A, Jones-Gotman M, Olivier A, Andermann E, Robitaille Y, Lopes-Cendes I et al (1993) Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study. Neurology 43:1083–1087

    CAS  PubMed  Google Scholar 

  21. Cendes F, Andermann F, Gloor P, Lopes-Cendes I, Andermann E, Melanson D, Jones-Gotman M, Robitaille Y, Evans A, Peters T (1993) Atrophy of mesial structures in patients with temporal lobe epilepsy: cause or consequence of repeated seizures? Ann Neurol 34:795–801

    Google Scholar 

  22. Cendes F, Andermann F, Dubeau F, Matthews PM, Arnold DL (1997) Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging. Neurology 49:1525–1533

    CAS  PubMed  Google Scholar 

  23. Cendes F, Caramanos Z, Andermann F, Dubeau F, Arnold DL (1997) Proton magnetic resonance spectroscopic imaging and magnetic resonance imaging volumetry in the lateralization of temporal lobe epilepsy: a series of 100 patients. Ann Neurol 42:737–746

    CAS  PubMed  Google Scholar 

  24. Connelly A, Jackson GD, Duncan JS, King MD, Gadian DG (1994) Magnetic resonance spectroscopy in temporal lobe epilepsy. Neurology 44:1411–1417

    CAS  PubMed  Google Scholar 

  25. Constantinidis I (2000) MRS methodology. Adv Neurol 83:235–246

    CAS  PubMed  Google Scholar 

  26. Daumas-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathol 3:283–295

    CAS  PubMed  Google Scholar 

  27. Devous MD Sr, Thisted RA, Morgan GF, Leroy RF, Rowe CC (1998) SPECT brain imaging in epilepsy: a meta-analysis. J Nucl Med 39:285–293

    PubMed  Google Scholar 

  28. Duncan JS (1997) Imaging and epilepsy. Brain 120:339–377

    Article  PubMed  Google Scholar 

  29. Duncan JS, Koepp MJ (2000) PET: central benzodiazepine neuroreceptor mapping in localization-related epilepsies. Adv Neurol 83:131–136

    CAS  PubMed  Google Scholar 

  30. Engel J Jr (2000) Overview of functional neuroimaging in epilepsy. Adv Neurol 83:1–9

    PubMed  Google Scholar 

  31. Engel J Jr (2001) Finally, a randomized, controlled trial of epilepsy surgery. N Engl J Med 345:365–367

    Article  PubMed  Google Scholar 

  32. Engel J Jr, Brown WJ, Kuhl DE, Phelps ME, Mazziotta JC, Crandall PH (1982) Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy. Ann Neurol 12:518–528

    Google Scholar 

  33. Engel J Jr, Kuhl DE, Phelps ME, Crandall PH (1982) Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. Ann Neurol 12:529–537

    Google Scholar 

  34. Engel J Jr, Kuhl DE, Phelps ME, Mazziotta JC (1982) Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes. Ann Neurol 12:510–517

    PubMed  Google Scholar 

  35. Forsyth PA, Shaw EG, Scheithauer BW, O'Fallon JR, Layton DD Jr, Katzmann JA (1993) Supratentorial pilocytic astrocytomas. A clinicopathologic, prognostic, and flow cytometric study of 51 patients. Cancer 72:1335–1342

    CAS  PubMed  Google Scholar 

  36. Gadian DG, Connelly A, Duncan JS, Cross JH, Kirkham FJ, Johnson CL, Vargha-Khadem F, Nevile BG, Jackson GD (1994) 1H magnetic resonance spectroscopy in the investigation of intractable epilepsy. Acta Neurol Scand Suppl 152:116–121

    CAS  PubMed  Google Scholar 

  37. Gaillard WD, Fazilat S, White S, Malow B, Sato S, Reeves P, Herscovitch P, Theodore WH (1995) Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. Neurology 45:1841–1847

    CAS  PubMed  Google Scholar 

  38. Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW (1995) Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Ann Neurol 37:279–281

    PubMed  Google Scholar 

  39. Gastaut H, Gastaut JL (1976) Computerized transverse axial tomography in epilepsy. Epilepsia 17:325–336

    CAS  PubMed  Google Scholar 

  40. Grafton ST (2000) PET: activation of cerebral blood flow and glucose metabolism. Adv Neurol 83:87–103

    CAS  PubMed  Google Scholar 

  41. Hajek M, Siegel AM, Haldemann R, von Schulthess GK, Wieser HG (1991) Value of HMPAO-SPECT in the selective temporal lobe surgery for epilepsy. J Epilepsy 4:43–51

    Google Scholar 

  42. Hajek M, Wieser HG, Khan N, Antonini A, Schrott PR, Maguire P, Beer HF, Leenders KL (1994) Preoperative and postoperative glucose consumption in mesiobasal and lateral temporal lobe epilepsy. Neurology 44:2125–2132

    CAS  PubMed  Google Scholar 

  43. Hammers A, Koepp MJ, Richardson MP, Labbe C, Brooks DJ, Cunningham VJ, Duncan JS (2001) Central benzodiazepine receptors in malformations of cortical development: a quantitative study. Brain 124:1555-1565

    Article  CAS  PubMed  Google Scholar 

  44. Hauser WA, Hesdorffer DC (1990) Epilepsy: frequency, causes and consequences. Demos, New York

  45. Henry TR, Babb TL, Engel J Jr, Mazziotta JC, Phelps ME, Crandall PH (1994) Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy. Ann Neurol 36:925–927

    Google Scholar 

  46. Ho SS, Berkovic SF, Berlangieri SU, Newton MR, Egan GF, Tochon-Danguy HJ, McKay WJ (1995) Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsy. Ann Neurol 37:738–745

    Google Scholar 

  47. Hugg JW, Laxer KD, Mattson GB (1992) 1H MR spectroscopic imaging detects neuron loss more sensitively than MRI in focal epilepsy. Proc Soc Magn Reson Med:1913

    Google Scholar 

  48. Hugg JW, Kuzniecky RI, Gilliam FG, Morawetz RB, Fraught RE, Hetherington HP (1996) Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging. Ann Neurol 40:236–239

    Google Scholar 

  49. Ildan F, Tuna M, Gocer IA, Erman T, Cetinalp E (2001) Intracerebral ganglioglioma: clinical and radiological study of eleven surgically treated cases with follow-up. Neurosurg Rev 24:114–118

    CAS  PubMed  Google Scholar 

  50. Jack CR (2000) Neuroimaging of the temporal lobe. In: Luders HO, Comair Y (eds) Epilepsy surgery, 2nd edn. Lippincott, Philadelphia, pp 227–237

  51. Jack CR Jr, Sharbrough FW, Twomey CK, Cascino GD, Hirschorn KA, Marsh WR, Zinsmeister AR, Scheithauer B (1990) Temporal lobe seizures: lateralization with MR volume measurements of the hippocampal formation. Radiology 175:423–429

    PubMed  Google Scholar 

  52. Jack CR Jr, Sharbrough FW, Cascino GD, Hirschorn KA, O'Brien PC, Marsh WR (1992) Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurol 31:138–146

    PubMed  Google Scholar 

  53. Jack CR Jr, Mullan BP, Sharbrough FW, Cascino GD, Hauser MF, Krecke KN, Luetmer PH, Trenerry MR, O'Brien PC, Parisi JE (1994) Intractable nonlesional epilepsy of temporal lobe origin: lateralization by interictal SPECT versus MRI. Neurology 44:829–836

    PubMed  Google Scholar 

  54. Jack CR Jr, Trenerry MR, Cascino GD, Sharbrough FW, So EL, O'Brien PC (1995) Bilaterally symmetric hippocampi and surgical outcome. Neurology 45:1353–1358

    PubMed  Google Scholar 

  55. Jack CR Jr, Rydberg CH, Krecke KN, Trenerry MR, Parisi JE, Rydberg JN, Cascino GD, Riederer SJ (1996) Mesial temporal sclerosis: diagnosis with fluid-attenuated inversion-recovery versus spin-echo MR imaging. Radiology 199:367–373

    PubMed  Google Scholar 

  56. Jackson GD, Berkovic SF, Duncan JS, Connelly A (1993) Optimizing the diagnosis of hippocampal sclerosis using MR imaging. AJNR Am J Neuroradiol 14:753–762

    CAS  PubMed  Google Scholar 

  57. Johnson JH Jr, Hariharan S, Berman J, Sutton LN, Rorke LB, Molloy P, Phillips PC (1997) Clinical outcome of pediatric gangliogliomas: ninety-nine cases over 20 years. Pediatr Neurosurg 27:203–207

    PubMed  Google Scholar 

  58. Kleihues P, Davis RL, Ohgaki H, Burger PC, Westphal MM, Cavanee WK (2000) Diffuse astrocytoma. In: Kleihues P, Cavanee WK (eds) Pathology and genetics: tumours of the nervous system, vol 1. International Agency for Research on Cancer, Lyon

  59. Koepp MJ, Richardson MP, Brooks DJ, Poline JB, Van Paesschen W, Friston KJ, Duncan JS (1996) Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis. Brain 119:1677–1687

    PubMed  Google Scholar 

  60. Kuzniecky RI (1995) Neuronal migration disorders. Neurology 45:2120

    CAS  Google Scholar 

  61. Kuzniecky RI, Barkovich AJ (2001) Malformations of cortical development and epilepsy. Brain Dev 23:2–11

    Article  CAS  PubMed  Google Scholar 

  62. Kuzniecky R, Andermann F, Tampieri D, Melanson D, Olivier A, Leppik I (1989) Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation—a recognizable neuronal migration disorder. Ann Neurol 25:547–554

    CAS  PubMed  Google Scholar 

  63. Kuzniecky R, Garcia JH, Faught E, Morawetz RB (1991) Cortical dysplasia in temporal lobe epilepsy: magnetic resonance imaging correlations. Ann Neurol 29:293–298

    CAS  PubMed  Google Scholar 

  64. Kuzniecky R, Murro A, King D, Morawetz R, Smith J, Powers R, Yaghmai F, Faught E, Gallagher B, Snead OC (1993) Magnetic resonance imaging in childhood intractable partial epilepsies: pathologic correlations. Neurology 43:681–687

    CAS  PubMed  Google Scholar 

  65. Lamusuo S, Pitkanen A, Jutila L, Ylinen A, Partanen K, Kalviainen R, Ruottinen HM, Oikonen V, Nagren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO (2000) [11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology. Neurology 54:2252–2260

    CAS  PubMed  Google Scholar 

  66. Lancman ME, Morris HH III, Raja S, Sullivan MJ, Saha G, Go R (1997) Usefulness of ictal and interictal 99mTc ethyl cysteinate dimer single photon emission computed tomography in patients with refractory partial epilepsy. Epilepsia 38:466–471

    CAS  PubMed  Google Scholar 

  67. Laxer KD (2000) Phosphorus MRS: pH, ATP, PCr. Adv Neurol 83:273–277

    CAS  PubMed  Google Scholar 

  68. Lee YY, Van Tassel P, Bruner JM, Moser RP, Share JC (1989) Juvenile pilocytic astrocytomas: CT and MR characteristics. AJR Am J Roentgenol 152:1263–1270

    CAS  PubMed  Google Scholar 

  69. Lewis PJ, Siegel A, Siegel AM, Studholme C, Sojkova J, Roberts DW, Thadani VM, Gilbert KL, Darcey TM, Williamson PD (2000) Does performing image registration and subtraction in ictal brain SPECT help localize neocortical seizures? J Nucl Med 41:1619–1626

    CAS  PubMed  Google Scholar 

  70. Li LM, Cendes F, Bastos AC, Andermann F, Dubeau F, Arnold DL (1998) Neuronal metabolic dysfunction in patients with cortical developmental malformations: a proton magnetic resonance spectroscopic imaging study. Neurology 50:755–759

    CAS  PubMed  Google Scholar 

  71. Martin RC, Sawrie SM, Knowlton RC, Bilir E, Gilliam FG, Faught E, Morawetz RB, Kuzniecky R (2001) Bilateral hippocampal atrophy: consequences to verbal memory following temporal lobectomy. Neurology 57:597–604

    CAS  PubMed  Google Scholar 

  72. Maton BM, Kuzniecky RI (2000) Proton MRS: N-acetyl aspartate, creatine, and choline. Adv Neurol 83:253–259

    CAS  PubMed  Google Scholar 

  73. Mattson RH (1992) Drug treatment of partial epilepsy. Adv Neurol 57:643–650

    CAS  PubMed  Google Scholar 

  74. Mottolese C, Hermier M, Stan H, Jouvet A, Saint-Pierre G, Froment JC, Bret P, Lapras C (2001) Central nervous system cavernomas in the pediatric age group. Neurosurg Rev 24:55–73

    CAS  PubMed  Google Scholar 

  75. Mullan BP, O'Connor MK, Hung JC (1995) Single photon emission computed tomography. Neuroimaging Clin N Am 5:647–673

    CAS  PubMed  Google Scholar 

  76. Muzik O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, Canady A, von Stockhausen HM, Herholz K, Gates J, Frost M, Ritter F, Watson C, Chugani HT (2000) Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology 54:171–179

    CAS  PubMed  Google Scholar 

  77. Nishio S, Morioka T, Hisada K, Fukui M (2000) Temporal lobe epilepsy: a clinicopathological study with special reference to temporal neocortical changes. Neurosurg Rev 23:84–89

    Article  CAS  PubMed  Google Scholar 

  78. Nishio S, Morioka T, Mihara F, Gondo K, Fukui M (2001) Cerebral ganglioglioma with epilepsy: neuroimaging features and treatment. Neurosurg Rev 24:14–19

    CAS  PubMed  Google Scholar 

  79. O'Brien TJ (2000) SPECT: methodology. Adv Neurol 83:11–32

    CAS  PubMed  Google Scholar 

  80. O'Brien TJ, Newton MR, Cook MJ, Berlangieri SU, Kilpatrick C, Morris K, Berkovic SF (1997) Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy. Epilepsia 38:74–80

    CAS  PubMed  Google Scholar 

  81. O'Brien TJ, O'Connor MK, Mullan BP, Brinkmann BH, Hanson D, Jack CR, So EL (1998) Subtraction ictal SPET co-registered to MRI in partial epilepsy: description and technical validation of the method with phantom and patient studies. Nucl Med Commun 19:31–45

    CAS  PubMed  Google Scholar 

  82. O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Bohnen NI, Hanson D, Cascino GD, Jack CR Jr, Sharbrough FW (1998) Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus. Neurology 50:445–454

    CAS  PubMed  Google Scholar 

  83. O'Brien TJ, Brinkmann BH, Mullan BP, So EL, Hauser MF, O'Connor MK, Hung J, Jack CR (1999) Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis. J Neurol Neurosurg Psychiatry 66:331–339

    CAS  PubMed  Google Scholar 

  84. O'Brien TJ, So EL, Meyer FB, Parisi JE, Jack CR (1999) Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy. Ann Neurol 45:526–529

    Article  CAS  PubMed  Google Scholar 

  85. O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Jack CR Jr, Cascino GD, Meyer FB, Sharbrough FW (1999) Substraction SPECT co-registered to MRI improves postictal SPECT localization of seizure foci. Neurology 52:137–146

    CAS  PubMed  Google Scholar 

  86. Oldendorf WH (1984) The use and promise of nuclear magnetic resonance imaging in epilepsy. Epilepsia 25 [Suppl 2]:S105–S117

  87. Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y (1991) Focal neuronal migration disorders and intractable partial epilepsy: results of surgical treatment. Ann Neurol 30:750–757

    Google Scholar 

  88. Privitera MD, Yeh HS, Blisard K, Sanchez N (2000) Detection of epileptogenic focal cortical dysplasia by depth, not subdural electrodes. Neurosurg Rev 23:49–51

    Article  CAS  PubMed  Google Scholar 

  89. Radhakrishnan K, So EL, Silbert PL, Jack CR Jr, Cascino GD, Sharbrough FW, O'Brien PC (1998) Predictors of outcome of anterior temporal lobectomy for intractable epilepsy: a multivariate study. Neurology 51:465–471

    CAS  PubMed  Google Scholar 

  90. Raymond AA, Halpin SF, Alsanjari N, Cook MJ, Kitchen ND, Fish DR, Stevens JM, Harding BN, Scaravilli F, Kendall B et al (1994) Dysembryoplastic neuroepithelial tumor. Features in 16 patients. Brain 117:461–475

    PubMed  Google Scholar 

  91. Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD (1995) Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain 118:629–660

    PubMed  Google Scholar 

  92. Richardson MP, Koepp MJ, Brooks DJ, Duncan JS (1998) 11C-flumazenil PET in neocortical epilepsy. Neurology 51:485–492

    CAS  PubMed  Google Scholar 

  93. Rowe CC, Berkovic SF, Austin MC, McKay WJ, Bladin PF (1991) Patterns of postictal cerebral blood flow in temporal lobe epilepsy: qualitative and quantitative analysis. Neurology 41:1096–1103

    CAS  PubMed  Google Scholar 

  94. Ryvlin P, Bouvard S, Le Bars D, De Lamerie G, Gregoire MC, Kahane P, Froment JC, Mauguiere F (1998) Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients. Brain 121:2067–2081

    Article  PubMed  Google Scholar 

  95. Sackellares JC, Siegel GJ, Abou-Khalil BW, Hood TW, Gilman S, McKeever PE, Hichwa RD, Hutchins GD (1990) Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. Neurology 40:1420–1426

    CAS  PubMed  Google Scholar 

  96. Sano K (2001) Intracranial dysembryogenetic tumors: pathogenesis and their order of malignancy. Neurosurg Rev 24:162–167

    CAS  PubMed  Google Scholar 

  97. Siegel AM, Roberts DW, Harbaugh RE, Williamson PD (2000) Pure lesionectomy versus tailored epilepsy surgery in treatment of cavernous malformations presenting with epilepsy. Neurosurg Rev 23:80–83

    Article  CAS  PubMed  Google Scholar 

  98. Sisodiya SM, Free SL, Stevens JM, Fish DR, Shorvon SD (1995) Widespread cerebral structural changes in patients with cortical dysgenesis and epilepsy. Brain 118:1039–1050

    PubMed  Google Scholar 

  99. So EL (2000) Integration of EEG, MRI, and SPECT in localizing the seizure focus for epilepsy surgery. Epilepsia 41 [Suppl 3]:S48–S54

  100. Spencer SS (1994) The relative contributions of MRI, SPECT, and PET imaging in epilepsy. Epilepsia 35 [Suppl 6]:S72–S89

    Google Scholar 

  101. Spencer SS, Bautista RE (2000) Functional neuroimaging in localization of the ictal onset zone. Adv Neurol 83:285–296

    CAS  PubMed  Google Scholar 

  102. Spencer SS, McCarthy G, Spencer DD (1993) Diagnosis of medial temporal lobe seizure onset: relative specificity and sensitivity of quantitative MRI. Neurology 43:2117–2124

    CAS  PubMed  Google Scholar 

  103. Stefan H, Bauer J, Feistel H, Schulemann H, Neubauer U, Wenzel B, Wolf F, Neundorfer B, Huk WJ (1990) Regional cerebral blood flow during focal seizures of temporal and frontocentral onset. Ann Neurol 27:162–166

    CAS  PubMed  Google Scholar 

  104. Stefan H, Hopp P, Platsch G, Kuwert T (2000) SPECT: ictal perfusion in localization-related epilepsies. Adv Neurol 83:41–50

    CAS  PubMed  Google Scholar 

  105. Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387

    CAS  PubMed  Google Scholar 

  106. Theodore WH (2000) PET: cerebral blood flow and glucose metabolism—pathophysiology and drug effects. Adv Neurol 83:121–130

    CAS  PubMed  Google Scholar 

  107. Theodore WH, Gaillard WD (2000) Positron emission tomography in neocortical epilepsies. Adv Neurol 84:435–446

    CAS  PubMed  Google Scholar 

  108. Theodore WH, Fishbein D, Dubinsky R (1988) Patterns of cerebral glucose metabolism in patients with partial seizures. Neurology 38:1201–1206

    CAS  PubMed  Google Scholar 

  109. Trenerry MR, Jack CR Jr, Ivnik RJ, Sharbrough FW, Cascino GD, Hirschorn KA, Marsh WR, Kelly PJ, Meyer FB (1993) MRI hippocampal volumes and memory function before and after temporal lobectomy. Neurology 43:1800–1805

    CAS  PubMed  Google Scholar 

  110. Trenerry MR, Jack CR Jr, Sharbrough FW, Cascino GD, Hirschorn KA, Marsh WR, Kelly PJ, Meyer FB (1993) Quantitative MRI hippocampal volumes: association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients. Epilepsy Res 15:247–252

    CAS  PubMed  Google Scholar 

  111. Urenjak J, Williams SR, Gadian DG, Noble M (1992) Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 59:55–61

    PubMed  Google Scholar 

  112. Urenjak J, Williams SR, Gadian DG, Noble M (1993) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13:981–989

    CAS  PubMed  Google Scholar 

  113. Zentner J, Hufnagel A, Wolf HK, Ostertun B, Behrens E, Campos MG, Elger CE, Wiestler OD, Schramm J (1997) Surgical treatment of neoplasms associated with medically intractable epilepsy. Neurosurgery 41:378–387

    CAS  PubMed  Google Scholar 

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  1. Division of Epilepsy, Department of Neurology, Mayo Clinic Foundation, 200 First Street SW, Rochester, MN 55905, USA

    Barbara Schäuble & Gregory D. Cascino

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  1. Barbara Schäuble
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  2. Gregory D. Cascino
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Correspondence to Gregory D. Cascino.

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Commentaries on this paper are available at http://dx.doi.org/10.1007/s10143-003-0294-5 and http://dx.doi.org/10.1007/s10143-003-0295-4

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Schäuble, B., Cascino, G.D. Advances in neuroimaging: management of partial epileptic syndromes. Neurosurg Rev 26, 233–246 (2003). https://doi.org/10.1007/s10143-003-0293-6

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  • DOI: https://doi.org/10.1007/s10143-003-0293-6

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