Skip to main content
Log in

Reversible delayed posthypoxic leukoencephalopathy after drug overdose: MRI findings in a collection of patients

  • Case Report
  • Published:
Emergency Radiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

References

  1. Arbelaez A, Castillo M, Mukherji SK (1999) Diffusion-weighted MR imaging of global cerebral anoxia. AJNR Am J Neuroradiol 20(6):999–1007

    PubMed  CAS  Google Scholar 

  2. Chalela JA, Wolf RL, Maldjian JA, Kasner SE (2001) MRI identification of early white matter injury in anoxic-ischemic encephalopathy. Neurology 56(4):481–485

    PubMed  CAS  Google Scholar 

  3. Falini A, Barkovich AJ, Calabrese G, Origgi D, Triulzi F, Scotti G (1998) Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study. AJNR Am J Neuroradiol 19(4):648–652

    PubMed  CAS  Google Scholar 

  4. Huang BY, Castillo M (2008) Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics 28(2):417–439. doi:10.1148/rg.282075066, quiz 617

    Article  PubMed  Google Scholar 

  5. Lo CP, Chen SY, Lee KW, Chen WL, Chen CY, Hsueh CJ, Huang GS (2007) Brain injury after acute carbon monoxide poisoning: early and late complications. AJR Am J Roentgenol 189(4):W205–W211. doi:10.2214/AJR.07.2425

    Article  PubMed  Google Scholar 

  6. Takahashi S, Higano S, Ishii K, Matsumoto K, Sakamoto K, Iwasaki Y, Suzuki M (1993) Hypoxic brain damage: cortical laminar necrosis and delayed changes in white matter at sequential MR imaging. Radiology 189(2):449–456

    PubMed  CAS  Google Scholar 

  7. Lee HB, Lyketsos CG (2001) Delayed post-hypoxic leukoencephalopathy. Psychosomatics 42(6):530–533

    Article  PubMed  Google Scholar 

  8. Molloy S, Soh C, Williams TL (2006) Reversible delayed posthypoxic leukoencephalopathy. AJNR Am J Neuroradiol 27(8):1763–1765

    PubMed  CAS  Google Scholar 

  9. Wallace IR, Dynan C, Esmonde T (2010) One confused patient, many confused physicians: a case of delayed post-hypoxic leucoencephalopathy. QJM 103(3):193–194. doi:10.1093/qjmed/hcp155

    Article  PubMed  CAS  Google Scholar 

  10. Choi IS (1983) Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol 40(7):433–435

    Article  PubMed  CAS  Google Scholar 

  11. Kim JH, Chang KH, Song IC, Kim KH, Kwon BJ, Kim HC, Han MH (2003) Delayed encephalopathy of acute carbon monoxide intoxication: diffusivity of cerebral white matter lesions. AJNR Am J Neuroradiol 24(8):1592–1597

    PubMed  Google Scholar 

  12. Aydin K, Sencer S, Demir T, Ogel K, Tunaci A, Minareci O (2002) Cranial MR findings in chronic toluene abuse by inhalation. AJNR Am J Neuroradiol 23(7):1173–1179

    PubMed  Google Scholar 

  13. Filley CM, Kleinschmidt-DeMasters BK (2001) Toxic leukoencephalopathy. N Engl J Med 345(6):425–432. doi:10.1056/NEJM200108093450606

    Article  PubMed  CAS  Google Scholar 

  14. Hill MD, Cooper PW, Perry JR (2000) Chasing the dragon—neurological toxicity associated with inhalation of heroin vapour: case report. Cmaj 162(2):236–238

    PubMed  CAS  Google Scholar 

  15. Ryan A, Molloy FM, Farrell MA, Hutchinson M (2005) Fatal toxic leukoencephalopathy: clinical, radiological, and necropsy findings in two patients. J Neurol Neurosurg Psychiatry 76(7):1014–1016. doi:10.1136/jnnp.2004.047134

    Article  PubMed  CAS  Google Scholar 

  16. Gottfried JA, Mayer SA, Shungu DC, Chang Y, Duyn JH (1997) Delayed posthypoxic demyelination. Association with arylsulfatase A deficiency and lactic acidosis on proton MR spectroscopy. Neurology 49(5):1400–1404

    PubMed  CAS  Google Scholar 

  17. Kwon OY, Chung SP, Ha YR, Yoo IS, Kim SW (2004) Delayed postanoxic encephalopathy after carbon monoxide poisoning. Emerg Med J 21(2):250–251

    Article  PubMed  CAS  Google Scholar 

  18. Heckmann JG, Erbguth F, Neundorfer B (1998) Delayed postanoxic demyelination registry. Neurology 51(4):1235–1236

    PubMed  CAS  Google Scholar 

  19. Weinberger LM, Schmidley JW, Schafer IA, Raghavan S (1994) Delayed postanoxic demyelination and arylsulfatase-A pseudodeficiency. Neurology 44(1):152–154

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aaron M. Betts.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Betts, A.M., Ritter, J.L. & Kubal, W.S. Reversible delayed posthypoxic leukoencephalopathy after drug overdose: MRI findings in a collection of patients. Emerg Radiol 19, 165–173 (2012). https://doi.org/10.1007/s10140-011-1013-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10140-011-1013-0

Keywords

Navigation