Skip to main content

Advertisement

SpringerLink
Log in

Learning from Small Fry: The Zebrafish as a Genetic Model Organism for Aquaculture Fish Species

  • Review Article
  • Published:
Marine Biotechnology Aims and scope Submit manuscript

Abstract

In recent years, the zebrafish has become one of the most prominent vertebrate model organisms used to study the genetics underlying development, normal body function, and disease. The growing interest in zebrafish research was paralleled by an increase in tools and methods available to study zebrafish. While zebrafish research initially centered on mutagenesis screens (forward genetics), recent years saw the establishment of reverse genetic methods (morpholino knock-down, TILLING). In addition, increasingly sophisticated protocols for generating transgenic zebrafish have been developed and microarrays are now available to characterize gene expression on a near genome-wide scale. The identification of loci underlying specific traits is aided by genetic, physical, and radiation hybrid maps of the zebrafish genome and the zebrafish genome project. As genomic resources for aquacultural species are increasingly being generated, a meaningful interaction between zebrafish and aquacultural research now appears to be possible and beneficial for both sides. In particular, research on nutrition and growth, stress, and disease resistance in the zebrafish can be expected to produce results applicable to aquacultural fish, for example, by improving husbandry and formulated feeds. Forward and reverse genetics approaches in the zebrafish, together with the known conservation of synteny between the species, offer the potential to identify and verify candidate genes for quantitative trait loci (QTLs) to be used in marker-assisted breeding. Moreover, some technologies from the zebrafish field such as TILLING may be directly transferable to aquacultural research and production.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  • A Amsterdam (2003) ArticleTitleInsertional mutagenesis in zebrafish Dev Dyn 228 523–534 Occurrence Handle10.1002/dvdy.10381

    Article  Google Scholar 

  • A Amsterdam N Hopkins (1999) ArticleTitleRetrovirus-mediated insertional mutagenesis in zebrafish Methods Cell Biol 60 87–98

    Google Scholar 

  • A Amsterdam S Burgess G Golling W Chen Z Sun K Townsend S Farrington M Haldi N Hopkins (1999) ArticleTitleA large-scale insertional mutagenesis screen in zebrafish Genes Dev 13 2713–2724 Occurrence Handle10.1101/gad.13.20.2713

    Article  Google Scholar 

  • S Aparicio J Chapman E Stupka N Putnam JM Chia P Dehal A Christoffels S Rash S Hoon A Smit MD Gelpke J Roach T Oh IY Ho M Wong C Detter F Verhoef P Predki A Tay S Lucas P Richardson SF Smith MS Clark YJ Edwards N Doggett A Zharkikh SV Tavtigian D Pruss M Barnstead C Evans H Baden J Powell G Glusman L Rowen L Hood YH Tan G Elgar T Hawkins B Venkatesh D Rokhsar S Brenner (2002) ArticleTitleWhole-genome shotgun assembly and analysis of the genome of Fugu rubripes Science 297 1301–1310 Occurrence Handle10.1126/science.1072104

    Article  Google Scholar 

  • CP Austin JF Battey A Bradley M Bucan M Capecchi FS Collins WF Dove G Duyk S Dymecki JT Eppig FB Grieder N Heintz G Hicks TR Insel A Joyner BH Koller KC Lloyd T Magnuson MW Moore A Nagy JD Pollock AD Roses AT Sands B Seed WC Skarnes J Snoddy P Soriano DJ Stewart F Stewart B Stillman H Varmus L Varticovski IM Verma TF Vogt H Melchner Particlevon J Witkowski RP Woychik W Wurst GD Yancopoulos SG Young B Zambrowicz (2004) ArticleTitleThe knockout mouse project Nat Genet 36 921–924 Occurrence Handle10.1038/ng0904-921

    Article  Google Scholar 

  • M Brand M Granato C Nüsslein-Volhard (2002) Keeping and raising zebrafish C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 7–37

    Google Scholar 

  • R Brooks (2002) ArticleTitleVariation in female mate choice within guppy populations: population divergence, multiple ornaments and the maintenance of polymorphism Genetica 116 343–358 Occurrence Handle10.1023/A:1021228308636

    Article  Google Scholar 

  • CM Carlson DA Largaespada (2005) ArticleTitleInsertional mutagenesis in mice: new perspectives and tools Nat Rev Genet 6 568–580 Occurrence Handle10.1038/nrg1638

    Article  Google Scholar 

  • W Chen S Burgess G Golling A Amsterdam N Hopkins (2002) ArticleTitleHigh-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish J Virol 76 2192–2198 Occurrence Handle10.1128/jvi.76.5.2192-2198.2002

    Article  Google Scholar 

  • M Clark DL Crawford A Cossins (2003) ArticleTitleMeeting review: Worldwide genomic resources for non-model fish species Comp Funct Genom 4 502–508 Occurrence Handle10.1002/cfg.324

    Article  Google Scholar 

  • GE Corley-Smith CJ Lim BP Brandhorst (1996) ArticleTitleProduction of androgenetic zebrafish (Danio rerio) Genetics 142 1265–1276

    Google Scholar 

  • AR Cossins DL Crawford (2005) ArticleTitleFish as models for environmental genomics Nat Rev Genet 6 324–333 Occurrence Handle10.1038/nrg1590

    Article  Google Scholar 

  • R Dahm (2002) Atlas of embryonic stages of development in the zebrafish C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 219–236

    Google Scholar 

  • R Dahm R Geisler C Nüsslein-Volhard (2005) Zebrafish (Danio rerio) genome and genetics RA Meyers (Eds) Encyclopedia of Molecular Cell Biology and Molecular Medicine EditionNumber2nd ed. Wiley-VCH Weinheim 593–626

    Google Scholar 

  • AE Davidson D Balciunas D Mohn J Shaffer S Hermanson S Sivasubbu MP Cliff PB Hackett SC Ekker (2003) ArticleTitleEfficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon Dev Biol 263 191–202 Occurrence Handle10.1016/j.ydbio.2003.07.013

    Article  Google Scholar 

  • W Driever L Solnica-Krezel AF Schier SC Neuhauss J Malicki DL Stemple DY Stainier F Zwartkruis S Abdelilah Z Rangini J Belak C Boggs (1996) ArticleTitleA genetic screen for mutations affecting embryogenesis in zebrafish Development 123 37–46

    Google Scholar 

  • S Ellingsen M Laplante M Konig T Furmanek H Kikuta E Høivik T Becker (2005) ArticleTitleLarge-scale enhancer detection in the zebrafish genome Development 132 IssueID17 3799–3811 Occurrence Handle10.1242/dev.01951

    Article  Google Scholar 

  • AL Felsenfeld C Walker M Westerfield C Kimmel G Streisinger (1990) ArticleTitleMutations affecting skeletal muscle myofibril structure in the zebrafish Development 108 443–459

    Google Scholar 

  • A Fire S Xu MK Montgomery SA Kostas SE Driver CC Mello (1998) ArticleTitlePotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 806–811 Occurrence Handle10.1038/35888

    Article  Google Scholar 

  • HG Frohnhoefer (2002) Table of zebrafish mutations C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 237–292

    Google Scholar 

  • M Furutani-Seiki J Wittbrodt (2004) ArticleTitleMedaka and zebrafish: an evolutionary twin study Mech Dev 121 629–637 Occurrence Handle10.1016/j.mod.2004.05.010

    Article  Google Scholar 

  • R Geisler (2002) Mapping and cloning C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 175–212

    Google Scholar 

  • R Geisler GJ Rauch H Baier F Bebber Particlevan L Broß MP Dekens K Finger C Fricke MA Gates H Geiger S Geiger-Rudolph D Gilmour S Glaser L Gnugge H Habeck K Hingst S Holley J Keenan A Kirn H Knaut D Lashkari F Maderspacher U Martyn S Neuhauss P Haffter et al. (1999) ArticleTitleA radiation hybrid map of the zebrafish genome Nat Genet 23 86–89 Occurrence Handle10.1038/12692

    Article  Google Scholar 

  • C Ghittino M Latini F Agnetti C Panzieri L Lauro R Ciappelloni G Petracca (2003) ArticleTitleEmerging pathologies in aquaculture: effects on production and food safety Vet Res Commun 27 IssueIDSuppl 1 471–479 Occurrence Handle10.1023/B:VERC.0000014204.37722.b6

    Article  Google Scholar 

  • DT Gilmour JR Jessen S Lin (2002) Manipulating gene expression in the zebrafish C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 121–143

    Google Scholar 

  • AS Glass R Dahm (2004) ArticleTitleThe zebrafish as a model organism for eye development Ophthal Res 36 4–24 Occurrence Handle10.1159/000076105

    Article  Google Scholar 

  • G Golling A Amsterdam Z Sun M Antonelli E Maldonado W Chen S Burgess M Haldi K Artzt S Farrington SY Lin RM Nissen N Hopkins (2002) ArticleTitleInsertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development Nat Genet 31 135–140 Occurrence Handle10.1038/ng896

    Article  Google Scholar 

  • C Grabher JS Joly J Wittbrodt (2004) ArticleTitleHighly efficient zebrafish transgenesis mediated by the meganuclease I-SceI Methods Cell Biol 77 381–401

    Google Scholar 

  • AY Gracey EJ Fraser W Li Y Fang RR Taylor J Rogers A Brass AR Cossins (2004) ArticleTitleCoping with cold: an integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate Proc Natl Acad Sci USA 101 16970–16975 Occurrence Handle10.1073/pnas.0403627101

    Article  Google Scholar 

  • P Haffter M Granato M Brand MC Mullins M Hammerschmidt DA Kane J Odenthal FJ Eeden Particlevan YJ Jiang CP Heisenberg RN Kelsh M Furutani-Seiki E Vogelsang D Beuchle U Schach C Fabian C Nusslein-Volhard (1996) ArticleTitleThe identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio Development 123 1–36

    Google Scholar 

  • ME Halpern RK Ho C Walker CB Kimmel (1993) ArticleTitleInduction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation Cell 75 99–111 Occurrence Handle10.1016/0092-8674(93)90682-G

    Article  Google Scholar 

  • GJ Hannon (2002) ArticleTitleRNA interference Nature 418 244–251 Occurrence Handle10.1038/418244a

    Article  Google Scholar 

  • W Harder (1975) Anatomy of Fishes E Schweizerbart’sche Verlagsbuchhandlung Stuttgart

    Google Scholar 

  • K Helde E Wilson C Cretekos D Grunwald (1994) ArticleTitleContribution of early cells to the fate map of the zebrafish gastrula Science 22 517–520

    Google Scholar 

  • R Ho D Kane (1990) ArticleTitleCell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors Nature 348 728–730 Occurrence Handle10.1038/348728a0

    Article  Google Scholar 

  • R Ho C Kimmel (1993) ArticleTitleCommitment of cell fate in the early zebrafish embryo Science 261 109–111

    Google Scholar 

  • NA Hukriede L Joly M Tsang J Miles P Tellis JA Epstein WB Barbazuk FN Li B Paw JH Postlethwait TJ Hudson LI Zon JD McPherson M Chevrette IB Dawid SL Johnson M Ekker (1999) ArticleTitleRadiation hybrid mapping of the zebrafish genome Proc Natl Acad Sci USA 96 9745–9750 Occurrence Handle10.1073/pnas.96.17.9745

    Article  Google Scholar 

  • O Jaillon JM Aury F Brunet JL Petit N Stange-Thomann E Mauceli L Bouneau C Fischer C Ozouf-Costaz A Bernot S Nicaud D Jaffe S Fisher G Lutfalla C Dossat B Segurens C Dasilva M Salanoubat M Levy N Boudet S Castellano V Anthouard C Jubin V Castelli M Katinka B Vacherie C Biemont Z Skalli L Cattolico J Poulain V Berardinis ParticleDe C Cruaud S Duprat P Brottier JP Coutanceau J Gouzy G Parra G Lardier C Chapple KJ McKernan P McEwan S Bosak M Kellis JN Volff R Guigo MC Zody J Mesirov K Lindblad-Toh B Birren C Nusbaum D Kahn M Robinson-Rechavi V Laudet V Schachter F Quetier W Saurin C Scarpelli P Wincker ES Lander J Weissenbach H Roest Crollius (2004) ArticleTitleGenome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype Nature 431 946–957 Occurrence Handle10.1038/nature03025

    Article  Google Scholar 

  • D Kane Y Kishimoto (2002) Cell labelling and transplantation techniques C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 95–119

    Google Scholar 

  • K Kawakami A Shima N Kawakami (2000) ArticleTitleIdentification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage Proc Natl Acad Sci USA 97 11403–11408 Occurrence Handle10.1073/pnas.97.21.11403

    Article  Google Scholar 

  • CB Kimmel WW Ballard SR Kimmel B Ullmann TF Schilling (1995) ArticleTitleStages of embryonic development of the zebrafish Dev Dyn 203 253–310

    Google Scholar 

  • EW Knapik (2000) ArticleTitlemutagenesis in zebrafish—from genes to complex diseases Mamm Genome 11 511–519 Occurrence Handle10.1007/s003350010098

    Article  Google Scholar 

  • EW Knapik A Goodman M Ekker M Chevrette J Delgado J Neuhauss N Shimoda W Driever MC Fishman HJ Jacob (1998) ArticleTitleA microsatellite genetic linkage map for zebrafish (Danio rerio) Nat Genet 18 IssueID4 338–343 Occurrence Handle10.1038/ng0498-338

    Article  Google Scholar 

  • R Koch G-J Rauch S Humphray R Geisler RHA Plasterk (2004) ArticleTitleBacterial artificial chromosome (BAC) clones and the current clone map of the zebrafish genome Methods Cell Biol 77 295–304

    Google Scholar 

  • S Kolkovski (2001) ArticleTitleDigestive enzymes in fish larvae and juveniles—implications and applications to formulated diets Aquaculture 200 181–201 Occurrence Handle10.1016/S0044-8486(01)00700-1

    Article  Google Scholar 

  • RW Koster SE Fraser (2001) ArticleTitleTracing transgene expression in living zebrafish embryos Dev Biol 233 329–346 Occurrence Handle10.1006/dbio.2001.0242

    Article  Google Scholar 

  • K Kurita SM Burgess N Sakai (2004) ArticleTitleTransgenic zebrafish produced by retroviral infection of in vitro-cultured sperm Proc Natl Acad Sci USA 101 1263–1267 Occurrence Handle10.1073/pnas.0304265101

    Article  Google Scholar 

  • T Kurokawa S Uji T Suzuki (2004) ArticleTitleIdentification of pepsinogen gene in the genome of stomachless fish, Takifugu rubripes Comp Biochem Physiol Pt B Biochem Mol Biol 140 133–140 Occurrence Handle10.1016/j.cbpc.2004.09.029

    Article  Google Scholar 

  • YX Li MJ Farrell R Liu N Mohanty ML Kirby (2000) ArticleTitleDouble-stranded RNA injection produces null phenotypes in zebrafish Dev Biol 217 394–405 Occurrence Handle10.1006/dbio.1999.9540

    Article  Google Scholar 

  • J Lo S Lee M Xu F Liu H Ruan A Eun Y He W Ma W Wang Z Wen J Peng (2003) ArticleTitle15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis Genome Res 2003 455–466 Occurrence Handle10.1101/gr.885403

    Article  Google Scholar 

  • S Mathavan SGP Lee A Mak LD Miller KRK Murthy et al. (2005) ArticleTitleTranscriptome analysis of zebrafish embryogenesis using microarrays PLoS Genet 1 e29 Occurrence Handle10.1371/journal.pgen.0010029

    Article  Google Scholar 

  • AH Meijer FJ Verbeek E Salas-Vidal M Corredor-Adamez J Bussman AM Sar Particlevan der GW Otto R Geisler HP Spaink (2005) ArticleTitleTranscriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection Mol Immunol 42 1184–1203 Occurrence Handle10.1016/j.molimm.2004.11.014

    Article  Google Scholar 

  • T Mizuno M Shinya H Takeda (1999) ArticleTitleCell and tissue transplantation in zebrafish embryos Methods Mol Biol 127 15–28

    Google Scholar 

  • CB Moens YL Yan B Appel AG Force CB Kimmel (1996) ArticleTitle valentino, a zebrafish gene required for normal hindbrain segmentation Development 122 3981–3990

    Google Scholar 

  • A Molina E Martino ParticleDi JA Martial M Muller (2001) ArticleTitleHeat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element Biochem J 356 353–359 Occurrence Handle10.1042/0264-6021:3560353

    Article  Google Scholar 

  • K Naruse H Hori N Shimizu Y Kohara H Takeda (2004) ArticleTitleMedaka genomics: a bridge between mutant phenotype and gene function Mech Dev 121 619–628 Occurrence Handle10.1016/j.mod.2004.04.014

    Article  Google Scholar 

  • A Nasevicius SC Ekker (2000) ArticleTitleEffective targeted gene 'knockdown' in zebrafish Nat Genet 26 216–220 Occurrence Handle10.1038/79951

    Article  Google Scholar 

  • JS Nelson (1994) Fishes of the World John Wiley & Sons New York

    Google Scholar 

  • JK Noveroske JS Weber MJ Justice (2000) ArticleTitleThe mutagenic action of N-ethyl-N-nitrosourea in the mouse Mamm Genome 11 478–483 Occurrence Handle10.1007/s003350010093

    Article  Google Scholar 

  • AC Oates AE Bruce RK Ho (2000) ArticleTitleToo much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo Dev Biol 224 20–28 Occurrence Handle10.1006/dbio.2000.9761

    Article  Google Scholar 

  • Otto GW (2001) The Zebrafish Genome: Strategies and Applications for Physical and Radiation Hybrid Mapping. PhD Thesis, FU Berlin

    Google Scholar 

  • F Pelegri (2002) Mutagenesis C Nüsslein-Volhard R Dahm (Eds) Zebrafish: A Practical Approach Oxford University Press Oxford 145–174

    Google Scholar 

  • JH Postlethwait IG Woods P Ngo-Hazelett YL Yan PD Kelly F Chu H Huang A Hill-Force WS Talbot (2000) ArticleTitleZebrafish comparative genomics and the origins of vertebrate chromosomes Genome Res 10 1890–1902 Occurrence Handle10.1101/gr.164800

    Article  Google Scholar 

  • JF Rawls BS Samuel JI Gordon (2004) ArticleTitleGnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota Proc Natl Acad Sci USA 101 4596–4601 Occurrence Handle10.1073/pnas.0400706101

    Article  Google Scholar 

  • E Raz HG Luenen Particlevan B Schaerringer RH Plasterk W Driever (1998) ArticleTitleTransposition of the nematode Caenorhabditis elegans Tc3 element in the zebrafish Danio rerio Curr Biol 8 82–88 Occurrence Handle10.1016/S0960-9822(98)70038-7

    Article  Google Scholar 

  • S Rieger R Kulkarni D Darcy S Fraser R Koster (2005) ArticleTitleQuantum dots are powerful multipurpose vital labeling agents in zebrafish embryos Dev Dyn 234 670–681 Occurrence Handle10.1002/dvdy.20524

    Article  Google Scholar 

  • E Ryder S Russell (2003) ArticleTitleTransposable elements as tools for genomics and genetics in Drosophila Brief Funct Genomic Proteomic 2 57–71 Occurrence Handle10.1093/bfgp/2.1.57

    Article  Google Scholar 

  • E Sarropoulou G Kotoulas DM Power R Geisler (2005) ArticleTitleGene expression profiling of gilthead sea bream during early development and detection of stress-related genes by the application of cDNA microarray technology Physiol Genom 23 182–191 Occurrence Handle10.1152/physiolgenomics.00139.2005

    Article  Google Scholar 

  • N Scheer JA Camnos-Ortega (1999) ArticleTitleUse of the Gal4-UAS technique for targeted gene expression in the zebrafish Mech Dev 80 153–158 Occurrence Handle10.1016/S0925-4773(98)00209-3

    Article  Google Scholar 

  • F Serluca M Fishman (1999) ArticleTitleCell lineage tracing in heart development Methods Cell Biol 59 359–365 Occurrence Handle10.1016/S0091-679X(08)61834-8

    Article  Google Scholar 

  • A Shima H Mitani (2004) ArticleTitleMedaka as a research organism: past, present and future Mech Dev 121 599–604 Occurrence Handle10.1016/j.mod.2004.03.011

    Article  Google Scholar 

  • Sonesson AK (2003) “Possibilitites for marker-assisted selection in fish breeding schemes.” In: FAO workshop: Marker Assisted Selection: A Fast Track to Increase Genetic Gain in Plant and Animal Breeding? Held 17–18 October 2003 in Turin, Italy (http://www.fao.org/biotach/Torino.htm)

  • G Streisinger C Walker N Dower D Knauber F Singer (1981) ArticleTitleProduction of clones of homozygous diploid zebra fish (Brachydanio rerio) Nature 291 293–296 Occurrence Handle10.1038/291293a0

    Article  Google Scholar 

  • GW Stuart JV McMurray M Westerfield (1988) ArticleTitleReplication, integration and stable germ-line transmission of foreign sequences injected into early zebrafish embryos Development 103 403–412

    Google Scholar 

  • M Tawk D Tuil Y Torrente S Vriz D Paulin (2002) ArticleTitleHigh-efficiency gene transfer into adult fish: a new tool to study fin regeneration Genesis 32 27–31 Occurrence Handle10.1002/gene.10025

    Article  Google Scholar 

  • C Tickle NJ Cole (2004) ArticleTitleMorphological diversity: taking the spine out of three-spine stickleback Curr Biol 14 R422–R424 Occurrence Handle10.1016/j.cub.2004.05.034

    Article  Google Scholar 

  • BJ Till T Colbert R Tompa LC Enns CA Codomo JE Johnson SH Reynolds JG Henikoff EA Greene MN Steine L Comai S Henikoff (2003) ArticleTitleHigh-throughput TILLING for functional genomics Methods Mol Biol 236 205–220

    Google Scholar 

  • C Ton D Stamatiou VJ Dzau CC Liew (2002) ArticleTitleConstruction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development Biochem Biophys Res Commun 296 1134–1142 Occurrence Handle10.1016/S0006-291X(02)02010-7

    Article  Google Scholar 

  • C Ton D Stamatiou CC Liew (2003) ArticleTitleGene expression profile of zebrafish exposed to hypoxia during development Physiol Genomics 13 97–106

    Google Scholar 

  • D Traver A Winzeler H Stern E Mayhall D Langenau J Kutok A Look Z Li (2004) ArticleTitleEffects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation Blood 104 1298–1305 Occurrence Handle10.1182/blood-2004-01-0100

    Article  Google Scholar 

  • D Vallone SB Gondi D Whitmore NS Foulkes (2004) ArticleTitleE-box function in a period gene repressed by light Proc Natl Acad Sci USA 101 4106–4111 Occurrence Handle10.1073/pnas.0305436101

    Article  Google Scholar 

  • AM Sar Particlevan der BJ Appelmelk CMJE Vandenbroucke-Grauls W Bitter (2004) ArticleTitleA star with stripes: zebrafish as an infection model Trends Microbiol 12 451–457 Occurrence Handle10.1016/j.tim.2004.08.001

    Article  Google Scholar 

  • A Wargelius S Ellingsen A Fjose (1999) ArticleTitleDouble-stranded RNA induces specific developmental defects in zebrafish embryos Biochem Biophys Res Commun 263 156–161 Occurrence Handle10.1006/bbrc.1999.1343

    Article  Google Scholar 

  • M Westerfield (2000) The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio) EditionNumber4th ed. University of Oregon Press Eugene

    Google Scholar 

  • E Wienholds S Schulte-Merker B Walderich RH Plasterk (2002) ArticleTitleTarget-selected inactivation of the zebrafish rag1 gene Science 297 99–102 Occurrence Handle10.1126/science.1071762

    Article  Google Scholar 

  • E Wienholds F Eeden Particlevan M Kosters J Mudde RH Plasterk E Cuppen (2003) ArticleTitleEfficient target-selected mutagenesis in zebrafish Genome Res 13 2700–2707 Occurrence Handle10.1101/gr.1725103

    Article  Google Scholar 

  • S Wilson SJ Easter (1991) ArticleTitleStereotyped pathway selection by growth cones of early epiphysial neurons in the embryonic zebrafish Development 112 723–746

    Google Scholar 

  • J Wittbrodt A Shima M Schartl (2002) ArticleTitleMedaka—a model organism from the far East Nat Rev Genet 3 53–64 Occurrence Handle10.1038/nrg704

    Article  Google Scholar 

  • Woo K, Shih J, Fraser S (1995) Fate maps of the zebrafish embryo. Curr Opin Genet Dev, 439–443

  • T Xiao W Shoji W Zhou F Su JY Kuwada (2003) ArticleTitleTransmembrane sema4E guides branchiomotor axons to their targets in zebrafish J Neurosci 23 4190–4198

    Google Scholar 

  • Z Zhao Y Cao M Li A Meng (2001) ArticleTitleDouble-stranded RNA injection produces nonspecific defects in zebrafish Dev Biol 229 215–223 Occurrence Handle10.1006/dbio.2000.9982

    Article  Google Scholar 

Download references

Acknowledgments

The authors would like to acknowledge the support of the European Commission (EC contracts LSHG-CT-2003-503496, ZF-MODELS, and QLRT-CT-2000-01797, BRIDGE-MAP). The authors are grateful to Martin Vötsch for technical assistance in the drawing of Figure 2.

Author information

Author notes

  1. Ralf Dahm

    Present address: Center for Brain Research, Division of Neuronal Cell Biology, Medical University of Vienna, A-1090, Vienna, Austria

Authors and Affiliations

  1. Department of Genetics, Max-Planck-Institute for Developmental Biology, D-72076, Tübingen, Germany

    Ralf Dahm & Robert Geisler

Authors
  1. Ralf Dahm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Geisler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ralf Dahm.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dahm, R., Geisler, R. Learning from Small Fry: The Zebrafish as a Genetic Model Organism for Aquaculture Fish Species. Mar Biotechnol 8, 329–345 (2006). https://doi.org/10.1007/s10126-006-5139-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10126-006-5139-0

Keywords

Search

Navigation