Background.
To elucidate the role that cyclin E overexpression plays in the progression of early gastric cancer, we examined the expression of cyclin E and p53, as abnormal p53 expression is linked with cyclin E overexpression in exerting adverse affects on the cell cycle.
Methods. Specimens from 108 early gastric cancers were stained by an immunohistochemical method, using anti-cyclin E and anti-p53 antibodies.
Results. The positivity rate of cyclin E expression in early gastric cancer was 33% (36/108). Cyclin E-positive tumors invaded more deeply (P < 0.05), infiltrated lymphatic vessels more frequently (P < 0.01), showed a higher incidence of differentiated cancer (P < 0.01), and more often expressed p53 (P < 0.01) than cyclin E-negative tumors. Differentiated cancers showing coexpression of cyclin E and p53 were more likely to metastasize to the lymph nodes.
Conclusions. Overexpression of cyclin E may promote the progression of early gastric cancer.
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Received for publication on Apr. 27, 1998; accepted on Nov. 17, 1998
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Jiaqing, L., Hokita, S., Xiangming, C. et al. Role of cyclin E and p53 expression in progression of early gastric cancer. Gastric Cancer 1, 160–165 (1998). https://doi.org/10.1007/s101200050011
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DOI: https://doi.org/10.1007/s101200050011