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Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

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Abstract

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite (TPU-x) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of ε-polylysine (ε-PL) and docusate sodium (DOSS). >99% reduction of colony forming unit (CFU) can be obtained in TPU-x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus (MRSA) and 0.5% for E. coli. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ∼100 nm. TPU-x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos. 51773201 and 51973212), the Bureau of Science and Technology of Changchun (No. 19SS005), the Department of Science and Technology of Jilin Province (No. 20200301017RQ) and the Joint Program of CAS-Jilin Province (No. 2019SYHZ0002).

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Authors and Affiliations

  1. Key Laboratory of Polymer Ecomaterials, Changehun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Xiao Liu, Jian-Wei Guo, Ya-Dong Liu, Ming Liu, Hui Liu, Miao-Miao Han & Sheng-Xiang Ji

  2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China

    Xiao Liu, Jian-Wei Guo, Hui Liu & Sheng-Xiang Ji

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  1. Xiao Liu
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  2. Jian-Wei Guo
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  3. Ya-Dong Liu
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  4. Ming Liu
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Correspondence to Miao-Miao Han or Sheng-Xiang Ji.

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Liu, X., Guo, JW., Liu, YD. et al. Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films. Chin J Polym Sci 39, 1020–1028 (2021). https://doi.org/10.1007/s10118-021-2578-z

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