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Antimicrobial Properties and Application of Polysaccharides and Their Derivatives

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Abstract

With the quick emergence of antibiotic resistance and multi-drug resistant microbes, more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge. Polysaccharides, as one of the major classes of biopolymers, were explored for their antimicrobial properties and applications, owing to their easy accessibility, biocompatibility and easy modification. Polysaccharides and their derivatives have variable demonstrations and applications as antimicrobial agents and antimicrobial biomaterials. A variety of polysaccharides, such as chitosan, dextran, hyaluronic acid, cellulose, other plant/animal-derived polysaccharides and their derivatives have been explored for antimicrobial applications. We expect that this review can summarize the important progress of this field and inspire new concepts, which will contribute to the development of novel antimicrobial agents in combating antibiotic resistance and drug-resistant antimicrobial infections.

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Acknowledgments

This work was financially supported by the Natural Science Foundation of Shanghai (No. 18ZR1410300), the National Natural Science Foundation of China (Nos. 21861162010, 21774031, and 31800801), the National Key Research and Development Program of China (No. 2016YFC1100401), and Research program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (Nos. 22221818014 and 50321041917001).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Gui-Xue Xia & Run-Hui Liu

  2. Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory of Specially Functional Polymeric Materials and Related Technology (ECUST) Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Yue-Ming Wu, Yu-Fang Bi, Kang Chen, Wei-Wei Zhang, Shi-Qi Liu, Wen-Jing Zhang & Run-Hui Liu

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  1. Gui-Xue Xia
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Correspondence to Run-Hui Liu.

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Xia, GX., Wu, YM., Bi, YF. et al. Antimicrobial Properties and Application of Polysaccharides and Their Derivatives. Chin J Polym Sci 39, 133–146 (2021). https://doi.org/10.1007/s10118-021-2506-2

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