Abstract
New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives (curdlan-Boc-histidine, CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L NaCl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin (BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different pH values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.
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This work was financially supported by the National Natural Science Foundation of China (Nos. 51028301 and 21174146) and the Special Funds for National Basic Research Program of China (No. 2009CB930100).
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Yang, Zc., Li, Yc., Li, F. et al. Design and preparation of pH-responsive curdlan hydrogels as a novel protein delivery vector. Chin J Polym Sci 34, 280–287 (2016). https://doi.org/10.1007/s10118-016-1757-9
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DOI: https://doi.org/10.1007/s10118-016-1757-9