Abstract
Biodegradable poly(L-lactide-r-trimethene carbonate) copolymers (P(LLA-co-TMC)) with different compositions were synthesized. The degradation of the copolymers was carried out in phosphate buffer saline solutions (pH = 7.4) at 37 °C. The compositions, structure and properties of the copolymers in degradation were characterized with 1H-NMR, DSC, XRD, GPC, and SEM. The weight loss of the P(LLA-co-TMC) 50/50 was much faster than that of P(LLA-co-TMC) 85/15 and PLLA homopolymer. Interestingly, though the molecular weight of the compolymers decreased greatly during degradation, the compositions were rarely varied. After long time degradation, the PLLA segments were induced to crystallize in the P(LLA-co-TMC) 85/15 copolymer. The SEM observation of the surface and cross-section of P(LLA-co-TMC) 85/15 copolymer films found it was similar to the bulk degradation of PLLA homopolymer.
Similar content being viewed by others
References
Drumright, R.E., Gruber, P.R. and Henton, D.E., Adv. Mater., 2000, 12: 1841
Tyson, T., Finne-Wistrand, A. and Albertsson, A.C., Biomacromolecules, 2009, 10: 149
Wistrand, A.F. and Albertsson, A.C., Chinese J. Polym. Sci., 2007, 25(2): 113
Pego, A.P., Vanluyn, M., Brouwer, L.A., Van Wachem, P.B., Poot, A.A., Grijpma, D.W. and Feijen, J., J. Biomed. Mater. Res., 2003, 67A: 1044
Ji, L.J., Lai, K.L., He, B., Wang, G., Song, L.Q., Wu, Y. and Gu, Z.W., Biomed. Mater., 2010, 5: 045009
Pego, A.P., Poot, A.A., Grijpma, D.W. and Feijen, J., J. Control. Release, 2003, 87: 69
Wang, L., Cai, C. and Dong, C.M., Chinese J. Polym. Sci., 2008, 26(2): 161
Wei, J.C., Sun, J.S., Wang, H.J., Chen, X.S. and Jing, X.B., Chinese J. Polym. Sci., 2010, 28(4): 499
He, B., Bei, J.Z. and Wang, S.G., Polymer, 2003, 44: 989
Lai, K.L., He, B. and Gu, Z.W., Chinese J. Polym. Sci., 2008, 26(2): 177
He, B., Wan, Y.Q., Bei, J.Z. and Wang, S.G., Acta Polymerica Sinica (in Chinese), 2004, (5): 693
Artham, T. and Doble, M., Macromol. Biosci., 2008, 8: 14
Wang, X.L., Zhuo, R.X., Liu, L.J., He, F. and Liu, G., J. Polym. Sci. A: Polym. Chem., 2002, 40: 70.
Wang, X.L., Zhuo, R.X., Huang, S.W., Liu, L.J. and He, F., Macromol. Chem. Phys., 2002, 203: 985
He, F., Wang, Y., Feng, J., Zhuo, R.X. and Wang, X., Polymer, 2003, 44: 3215
Lai, K.L., Ji L.J., Long, C.Y, Li, L., He, B., Wu, Y. and Gu, Z.W., J. Appl. Polym. Sci., 2012, 123: 2204
Long, C.Y., Sheng, M.M., He, B., Wu, Y., Wang, G. and Gu, Z.W., Chinese J. Polym. Sci., 2012, 30(3): 387
Odelius, K., Plikk, P. and Albertsson, A.C., Biomacromolecules, 2005, 6: 2718
Stridsberg, K. and Albertsson A.C., J. Polym. Sci. Part A: Polym. Chem., 2000, 38: 1774
Andronova, N. and Albertsson, A.C., Biomacromolecules, 2006, 7: 1489
Odelius, K. and Albertsson, A.C., J. Polym. Sci. Part A: Polym. Chem., 2008, 46: 1249
Pego, A.P., Grijpma, D.W. and Feijen, J., Polymer, 2003, 44: 6495
Song, Y., Kamphuis, M.M.J., Zhang, Z., Sterk, L.M., Vermes, I., Poot, A.A., Feijen, J. and Grijpma, D.W., Acta Biomaterialia, 2010, 6: 1269
Pitt, C.G. and Gu, Z.W., J. Control. Release, 1987, 4: 283
Zhang, Z., Kuijer, R., Bulstra, S.K., Grijpma, D.W. and Feijen, J., Biomaterials, 2006, 27: 1741
Zhang, Z., Zou, S., Vancso, G.J., Grijpma, D.W. and Feijen, J., Biomacromolecules, 2005, 6: 3404
He, B., Bei, J.Z. and Wang, S.G., Polym. Adv. Technol., 2003, 14(9): 645
Author information
Authors and Affiliations
Corresponding author
Additional information
This work was financially supported by the National Basic Research Program of China (National 973 program, No. 2011CB606206), the National Natural Science Foundation of China (Nos. 50830105, 51133004), Program for New Century Excellent Talents in Universities, Ministry of Education (MOE, NCET-10-0564) and Program for Changjiang Scholars and Innovative Research Teams in Universities (IRT1163).
Rights and permissions
About this article
Cite this article
Li, Yl., Li, S., Ji, Lj. et al. Studies on the degradation of poly(L-lactide-r-trimethene carbonate) copolymers. Chin J Polym Sci 31, 966–973 (2013). https://doi.org/10.1007/s10118-013-1299-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10118-013-1299-3