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Acute effect of photobiomodulation therapy on handgrip strength of chronic kidney disease patients during hemodialysis

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Abstract

Pre-exercise photobiomodulation therapy (PBMT) reduces fatigue and enhances performance in different populations. However, PBMT benefits have never been tested on chronic kidney disease (CKD) patients, who present muscle weakness, fatigue, and reduced functional performance. The objective of this study was to evaluate the acute effect of three different doses of the PBMT on maximal handgrip strength of CKD patients. Fifteen volunteers (58 ± 8 years, 10 male/5 female) under chronic hemodialysis treatment (6 ± 4 years) participated in a randomized, crossover, double-blind, placebo-controlled trial. Each patient was assessed at four hemodialysis sessions with 1 week interval between evaluations. Placebo or PBMT (cluster probe with five 850 nm/200 mW laser diodes) were applied at three sites along the flexors of the finger (total doses of 60, 90, or 120 J per arm). The maximal handgrip strength was evaluated before and after PBMT/placebo treatment in each session. Repeated measures ANOVA and intraclass correlation coefficients (ICC) confirmed no learning effect on handgrip tests, and high scores for test-retest reliability (ICC scores = 0.89 to 0.95). Significant strength increases occurred after PBMT application with doses of 60 J/arm (4.85%, p = 0.005, ES = 0.32) and 90 J/arm (4.45%, p = 0.013, ES = 0.25), while no changes were detected with placebo or 120 J/arm. In conclusion, in consensus with a recent systematic review, a single bout of the 60 J/arm was the best dose/response for increased strength of the small muscles (handgrip strength). In view of the increasing implementation of exercise programs during hemodialysis, the current study opens a new field for PBMT for CKD patients.

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Authors and Affiliations

  1. Graduate Program in Rehabilitation Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Sarmento Leite, 245, Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

    Fabrício Edler Macagnan, Bruno Manfredini Baroni & Rodrigo Della Méa Plentz

  2. Physiotherapy Course, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Érika Zanchet Cristofoli & Marília Godoy

  3. Graduate Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Jociane Schardong & Rodrigo Della Méa Plentz

Authors
  1. Fabrício Edler Macagnan
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  2. Bruno Manfredini Baroni
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  3. Érika Zanchet Cristofoli
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  4. Marília Godoy
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  5. Jociane Schardong
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  6. Rodrigo Della Méa Plentz
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Correspondence to Fabrício Edler Macagnan.

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The authors declare that they have no conflict of interest.

Ethical approval

The Research Ethics Committees approved this study (CAAE: 34811314.4.0000.5335), and the recruitments start only after ClinicalTrials.gov endorsement (NCT02586376).

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Macagnan, F.E., Baroni, B.M., Cristofoli, É.Z. et al. Acute effect of photobiomodulation therapy on handgrip strength of chronic kidney disease patients during hemodialysis. Lasers Med Sci 34, 835–840 (2019). https://doi.org/10.1007/s10103-018-2593-7

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  • DOI: https://doi.org/10.1007/s10103-018-2593-7

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