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Optical coherence tomography to evaluate variance in the extent of carious lesions in depth

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Abstract

Evaluation of variance in the extent of carious lesions in depth at smooth surfaces within the same ICDAS code group using optical coherence tomography (OCT) in vitro and in vivo. (1) Verification/validation of OCT to assess non-cavitated caries: 13 human molars with ICDAS code 2 at smooth surfaces were imaged using OCT and light microscopy. Regions of interest (ROI) were categorized according to the depth of carious lesions. Agreement between histology and OCT was determined by unweighted Cohen’s Kappa and Wilcoxon test. (2) Assessment of 133 smooth surfaces using ICDAS and OCT in vitro, 49 surfaces in vivo. ROI were categorized according to the caries extent (ICDAS: codes 0–4, OCT: scoring based on lesion depth). A frequency distribution of the OCT scores for each ICDAS code was determined. (1) Histology and OCT agreed moderately (κ = 0.54, p ≤ 0.001) with no significant difference between both methods (p = 0.25). The lesions (76.9% (10 of 13)) _were equally scored. (2) In vitro, OCT revealed caries in 42% of ROI clinically assessed as sound. OCT detected dentin-caries in 40% of ROIs visually assessed as enamel-caries. In vivo, large differences between ICDAS and OCT were observed. Carious lesions of ICDAS codes 1 and 2 vary largely in their extent in depth.

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Acknowledgements

The authors would like to thank Ms. Claudia Rueger, Mr. Tobias Meissner, and Ms. Annett Schumann for the professional technical assistance.

Funding

The study was funded by the European Regional Development Fund (ERDF) [100175024; 100175035].

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Authors and Affiliations

  1. Department of Cariology, Endodontology, and Periodontology, University of Leipzig, Liebig Str.12, Haus 1, 04103, Leipzig, Germany

    Kyung-Jin Park, Hartmut Schneider, Dirk Ziebolz, Felix Krause & Rainer Haak

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  1. Kyung-Jin Park
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  2. Hartmut Schneider
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  3. Dirk Ziebolz
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  4. Felix Krause
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  5. Rainer Haak
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Corresponding author

Correspondence to Kyung-Jin Park.

Ethics declarations

The studies were conducted in accordance with the Declaration of Helsinki, and the protocols were approved by the Ethics Committee of the University of Leipzig. The extracted teeth were used on the basis of patients’ approvals (protocol no. 299-10-04102010). All subjects gave their informed consent for inclusion before they participated in the study and signed the consent declaration (protocol no.: 394-13-16122013, reference no.: 394/13-ff).

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The authors declare that they have no conflict of interest.

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Park, KJ., Schneider, H., Ziebolz, D. et al. Optical coherence tomography to evaluate variance in the extent of carious lesions in depth. Lasers Med Sci 33, 1573–1579 (2018). https://doi.org/10.1007/s10103-018-2522-9

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  • DOI: https://doi.org/10.1007/s10103-018-2522-9

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