Abstract
Herein, the performance of single-fiber reflectance spectroscopy (SFRS) in detection of cervical pre-cancerous squamous intraepithelial lesions (SIL) was compared with colposcopy. Based on the previous results obtained from 167 samples and finding the contributing parameters in differentiating SILs from non-SILs, a user-friendly interface was developed to detect the SILs using SFRS system. Detection of SILs in 301 patients was performed by both SFRS system and routine colposcopy. In addition to physician-determined sites, four quarters of the cervix were measured by SFRS system and suspicious lesions detected by either method were biopsied. Histopathologic results of the biopsied species were compared to the physician judgments based on colposcopy and the results of SFRS system. SFRS could differentiate between SILs and non-SILs with mean sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 38.3, 60.9, 15.2, and 84.3%, respectively. These values were obtained as 88.3, 10.6, 15.4, and 83.1% for the colposcopy, respectively. Although sensitivity of SFRS in detection of SILs is about twofold less than the colposcopy, it can reduce the number of unnecessary biopsies by a factor of more than 5.5. Therefore, the aid of SFRS system to the physician can reduce the number of unnecessary biopsies. On the other hand, both colposcopy and SFRS methods equally suffer from low detection worth in terms of positive/negative predictive values. In conclusion, using the online, simple and non-invasive SFRS system to choose between several suspicious sites in a patient in the clinic may be recommended.
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Acknowledgments
We cordially acknowledge the contribution of the gynecology residents, Dr. Fatehi, Dr. Salimi, Dr. Saraeian, Dr. Ghanbarpour, Dr. Mostafa, Dr. Fereidonjah, Dr. Defaei, Dr. Khosravi, Dr. Asadollahi, and Dr. Ashori. Also, the staff of the gynecology department of Emam Hossein Hospital deserves gratitude. We would also like to thank all the patients who participated in this study. The study was supported by Shahid Beheshti University of Medical Sciences under grant number 13/1630.
Funding
The study was funded by Shahid Beheshti University of Medical Sciences (grant number 13/1630).
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All procedures in this study were in accordance with the ethical standards of Shahid Beheshti University of Medical Sciences research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in this study.
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Hariri Tabrizi, S., Farzaneh, F., Aghamiri, S.M.R. et al. Comparison between performance of single-fiber reflectance spectroscopy (SFRS) system and colposcopy: a phase III trial. Lasers Med Sci 32, 2139–2144 (2017). https://doi.org/10.1007/s10103-017-2353-0
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DOI: https://doi.org/10.1007/s10103-017-2353-0