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Comparison of the efficacy and feasibility of laser enucleation of bladder tumor versus transurethral resection of bladder tumor: a meta-analysis

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Abstract

The transurethral resection of bladder tumor (TURBT) remains the most widely used method in the surgical treatment of the non-muscle invasive bladder tumor (NMIBT). Despite its popularity, the laser technique has been widely used in urology as an alternative, via the application of transurethral laser enucleation of bladder tumor. The aim of the present study was to compare the efficacy and feasibility between transurethral laser enucleation and transurethral resection of bladder tumor. A systematic search of the following databases was conducted: PubMed, Wed of Science, Cochrane Library, EMBASE, Google scholar, and Medline. The search included studies up to the 1st of January 2017. The outcomes of interest that were used in order to assess the two techniques included operation time, catheterization time, hospitalization time, obturator nerve reflex, bladder perforation, bladder irritation, 24-month-recurrence rate, and the postoperative adjuvant intravesical chemotherapy. A total of 13 trials with 2012 participants were included, of which 975 and 1037 underwent transurethral laser enucleation and transurethral resection of bladder tumor, respectively. No significant difference was noted in the operation time between the two groups, although significant differences were reported for the variables catheterization time, hospitalization time, obturator nerve reflex, bladder perforation, bladder irritation, and 24-month-recurrence rate. In the mitomycin and epirubicin subgroups, no significant differences were observed in the laser enucleation and TURBT methods with regard to the 24-month-recurrence rate. The laser enucleation was superior to TURBT with regard to the parameters obturator nerve reflex, bladder perforation, catheterization time, hospitalization time, and 24-month-recurrence rate. Moreover, laser enucleation can offer a more accurate result of the tumor’s pathological stage and grade.

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The role of funding source

The work was supported by Independent innovation research fund of Huazhong University of Science and Technology, China; Award Number: 1802030.

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Authors and Affiliations

  1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Huan Yang, Ning Wang, Shanfu Han, Musa Male, Chenming Zhao & Zhiqiang Chen

  2. Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Huan Yang, Ning Wang, Shanfu Han, Musa Male, Chenming Zhao & Zhiqiang Chen

  3. Department of Urology, Luohe Centeral Hospital, Luohe, Henan province, 462000, China

    Daqiang Yao

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  1. Huan Yang
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  2. Ning Wang
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  3. Shanfu Han
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  4. Musa Male
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  5. Chenming Zhao
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Correspondence to Zhiqiang Chen.

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All analyses were based on previous published studies, thus no ethical approval and patient consent are required.

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The authors declare that they have no competing interest.

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Yang, H., Wang, N., Han, S. et al. Comparison of the efficacy and feasibility of laser enucleation of bladder tumor versus transurethral resection of bladder tumor: a meta-analysis. Lasers Med Sci 32, 2005–2012 (2017). https://doi.org/10.1007/s10103-017-2308-5

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  • DOI: https://doi.org/10.1007/s10103-017-2308-5

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