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UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

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Abstract

UVA1 phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of palmoplantar pustulosis (PPP). The purpose of this study was to compare the efficacy of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of PPP. Patients with PPP were randomly assigned to either UVA1 or NB-UVB therapy according to a left-right randomization table. Both treatments were performed three times weekly for up to 30 sessions. Clinical evaluation was based on the Palmoplantar Pustular Psoriasis Area and Severity Index (PPPASI) score. Totally 64 patients completed the study. Both UVA1 and NB-UVB therapy showed a statistically significant reduction of PPPASI score compared with the baseline value at the end of the treatment period (P < 0.05). There was a significantly greater mean reduction of PPPASI score in the UVA1 treated group when compared to the NB-UVB treated patients at 30 sessions (6.0 ± 2.4 vs. 4.4 ± 1.4, P < 0.05). No phototoxic reaction or bullous changes were observed in either group. Both NB-UVB and UVA1 phototherapy of PPP resulted in significant improvement. UVA1 phototherapy was more effective than NB-UVB irradiation in the treatment of PPP.

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Acknowledgments

This study was supported by grant from the Natural Science Foundation of Shanghai Municipal Commission of Health and Family Planning (201640188).

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Author notes

  1. Li-na Su and Jie Ren contributed equally to this work

Authors and Affiliations

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

    Li-na Su, Jie Ren, Shi-meng Cheng, Jian-lan Liu & Ning-wen Zhu

  2. Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University, Shanghai, People’s Republic of China

    Li-na Su & Yang-feng Ding

Authors
  1. Li-na Su
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  2. Jie Ren
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  3. Shi-meng Cheng
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  4. Jian-lan Liu
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  6. Ning-wen Zhu
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Correspondence to Li-na Su.

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The authors declare that they have no conflict of interest.

Ethics statement

This study was approved by the Ethics Committee of Huashan Hospital and conducted in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Su, Ln., Ren, J., Cheng, Sm. et al. UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study. Lasers Med Sci 32, 1819–1823 (2017). https://doi.org/10.1007/s10103-017-2280-0

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  • DOI: https://doi.org/10.1007/s10103-017-2280-0

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