Skip to main content
Log in

Efficacy and safety of fractional carbon dioxide laser for treatment of unwanted facial freckles in phototypes II–IV: a pilot study

  • Original Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

An Erratum to this article was published on 11 July 2014

Abstract

Facial freckles are a cosmetic concern to Egyptians, particularly young females. Several therapeutic lines exist with variable response rates and limitations. Fractional carbon dioxide (FCO2) laser provides minimal ablation and therefore less down time and less side effects. The efficacy and safety of this laser technology have still not been studied in freckles. The aim of this study is to assess the efficacy and safety of FCO2 laser in the treatment of unwanted facial freckles in Egyptians. Twenty patients undergone a single session of FCO2 laser and then were followed up clinically a month later. Photographs were taken before treatment and at follow-up visit and were assessed by three blinded investigators. Percent of global improvement was measured on a 4-point grading scale. Patient’s satisfaction and adverse events were recorded. Two patients (10 %) showed grade 1 improvement, while eight patients (40 %) showed grade 2 improvement. Nine patients (45 %) showed grade 3 improvement, and only one patient (5 %) showed grade 4 improvement. FCO2 laser resurfacing is effective and safe in treatment of facial freckles in skin phototypes II–IV. It can offer a more practical alternative to topical treatments, and a cheaper alternative to Q-switched lasers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Newton-Bishop JA. Lentigos, melanocytic nevi and melanoma (2010) In: Burns et al (ed) Rooks textbook of dermatology, 8th edn. Blackwell publishing Ltd, UK, pp. 541-545

  2. Bastiaens M, ter Huurne J, Gruis N, Bergman W (2001) The melanocortin-1-receptor gene is the major freckle gene. Hum Mol Genet 10(16):1701–1708

    Article  PubMed  CAS  Google Scholar 

  3. Halder RM, Richards GM (2004) Topical agents used in the management of hyperpigmentation. Skin Ther Newsl 9(6):1–3

    CAS  Google Scholar 

  4. Cayce KA, Feldman SR, McMichael AJ (2004) Hyperpigmentation: a review of common treatment options. J Drugs Dermatol 3(6):668–673

    PubMed  Google Scholar 

  5. Gold MH, Gallagher C (2013) An evaluation of the benefits of a topical treatment in the improvement of photodamaged hands with age spots, freckles, and/or discolorations. J Drugs Dermatol 12(12):1468–1472

    PubMed  Google Scholar 

  6. Mradula PR, Sacchidanand S (2012) A split-face comparative study of 70% trichloroacetic acid and 80% phenol spot peel in the treatment of freckles. J Cutan Aesthet Surg 5(4):261–265

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Ho SG, Yeung CK, Chan NP, Shek SY et al (2011) A comparison of Q-switched and long-pulsed alexandrite laser for the treatment of freckles and lentigines in oriental patients. Lasers Surg Med 43(2):108–113

    Article  PubMed  CAS  Google Scholar 

  8. Ho SG, Chan NP, Yeung CK, Shek SY et al (2012) A retrospective analysis of the management of freckles and lentigines using four different pigment lasers on Asian skin. J Cosmet Laser Ther 14(2):74–80

    Article  PubMed  CAS  Google Scholar 

  9. Jang KA, Chung EC, Choi JH, Sung KJ et al (2000) Successful removal of freckles in Asian skin with a Q-switched alexandrite laser. Dermatol Surg 26(3):231–234

    Article  PubMed  CAS  Google Scholar 

  10. Rashid T, Hussain I, Haider M, Haroon TS (2002) Laser therapy of freckles and lentigines with quasi-continuous, frequency-doubled, Nd:YAG (532 nm) laser in Fitzpatrick skin type IV: a 24-month follow-up. J Cosmet Laser Ther 4(3–4):81–85

    Article  PubMed  CAS  Google Scholar 

  11. Wang CC, Sue YM, Yang CH, Chen CK (2006) A comparison of Q-switched alexandrite laser and intense pulsed light for the treatment of freckles and lentigines in Asian persons: a randomized, physician-blinded, split-face comparative trial. J Am Acad Dermatol 54(5):804–810

    Article  PubMed  Google Scholar 

  12. Park JM, Tsao H, Tsao S (2008) Combined use of intense pulsed light and Q-switched ruby laser for complex dyspigmentation among Asian patients. Lasers Surg Med 40(2):128–133

    Article  PubMed  Google Scholar 

  13. Suh DH, Han KH, Chung JH (2001) The use of Q-switched Nd:YAG laser in the treatment of superficial pigmented lesions in Koreans. J Dermatol Treat 12:91–96

    Article  CAS  Google Scholar 

  14. Gold MH (2010) Update on fractional laser technology. J Clin Aesthet Dermatol 3(1):42–50

    Google Scholar 

  15. Bogdan AI, Kaufman J (2010) Fractional photothermolysis—an update. Lasers Med Sci 25(1):137–144

    Article  Google Scholar 

  16. Tierney EP, Eisen RF, Hanke CW (2011) Fractionated CO2 laser skin rejuvenation. Dermatol Ther 24(1):41–53

    Article  PubMed  Google Scholar 

  17. Le Pillouer-Prost A, Zerbinati N (2008) Fractional laser resurfacing with SmartXide DOT. Initial results. Internet 1-4. http://www.co2fracionado.com.br/artigos/White-Paper.pdf. Accessed Nov 2012.

  18. Trelles MA, Velez M, Gold MH (2010) The treatment of melasma with topical creams alone, CO2 fractional ablative resurfacing alone, or a combination of the two: a comparative study. J Drugs Dermatol 9(4):315–322

    PubMed  Google Scholar 

  19. Neeley MR, Pearce FB, Collawn SS (2010) Successful treatment of malar dermal melasma with a fractional ablative CO2 laser in a patient with type V skin. J Cosmet Laser Ther 12(6):258–260

    Article  PubMed  Google Scholar 

  20. Polder KD, Landau JM, Vergilis-Kalner IJ, Goldberg LH et al (2011) Laser eradication of pigmented lesions: a review. Dermatol Surg 37(5):572–595

    Article  PubMed  CAS  Google Scholar 

  21. Tierney EP, Hanke CW (2011) Fractionated carbon dioxide laser treatment of photoaging: prospective study in 45 patients and review of the literature. Dermatol Surg 37(9):1279–1290

    Article  PubMed  CAS  Google Scholar 

  22. Laubach HJ, Tannous Z, Anderson RR, Manstein D (2006) Skin responses to fractional photothermolysis. Lasers Surg Med 38(2):142–149

    Article  PubMed  Google Scholar 

  23. Kauvar ANB, Warycha MA (2011) Wrinkles and acne scars: fractional ablative lasers. In: Raulin C, Karsai S (eds) Laser and IPL technology in dermatology and aesthetic medicine. Springer, Berlin Heidelberg, pp 307–318

    Chapter  Google Scholar 

  24. Ruiz-Esparza J, Lupton JR (2002) Laser resurfacing of darkly pigmented patients. Dermatol Clin 20(1):113–121

    Article  PubMed  Google Scholar 

  25. Nouri K, Vidulich K, Rivas MP (2006) Lasers for scars: a review. J Cosmet Dermatol 5(1):14–22

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Funding sources

The laser sessions were performed free of charge, in the laser unit of Dermatology department, Kasr Al Ainy teaching hospital, Cairo University. Medications were partly dispensed by the out-patient clinic and partly sponsored by the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vanessa Hafez.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

El Zawahry, B., Zaki, N., Hafez, V. et al. Efficacy and safety of fractional carbon dioxide laser for treatment of unwanted facial freckles in phototypes II–IV: a pilot study. Lasers Med Sci 29, 1937–1942 (2014). https://doi.org/10.1007/s10103-014-1610-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-014-1610-8

Keywords

Navigation