Skip to main content
SpringerLink
Log in

Development of the theragnostic optical system for a high-intensity laser therapy (HILT)

  • Original Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

Abstract

Recently, high-intensity laser therapy (HILT) has been introduced for muscle disorders, but its efficacy has not been confirmed due to the absence of quantitative assessments and treatment feedback data in real-time. In this clinical study, a theragnostic optical system comprised of a high-intensity laser and a non-invasive optical monitoring system was developed to assess spasticity. To avoid interference between the two different light sources, the therapeutic wavelength for HILT was selected at 808 nm, one of the isosbestic points. The monitoring system based on a near-infrared spectroscopy (NIRS) was utilized for measuring hemoglobin concentrations according to a modified Beer-Lambert’s law. The transitory HILT effect was evaluated from patients experiencing spasticity after stroke. Our results showed the proportionate relationship between manual muscle testing grades and the HILT effect on hemiplegic patients. The developed system proved to be useful for the simultaneous assessment and treatment of spasticity, and it holds promise for real-time monitoring of hemoglobin concentrations during laser therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Lamontagne A, Malouin F, Richards CL, Dumas F (1998) Evaluation of reflex- and nonreflex-induced muscle resistance to stretch in adults with spinal cord injury using hand-held and isokinetic dynamometry. Phys Ther 78(9):964–975

    CAS  PubMed  Google Scholar 

  2. Bhakta BB (2000) Management of spasticity in stroke. Br Med Bull 56(2):476–485

    Article  CAS  PubMed  Google Scholar 

  3. Taylor JL, Butler JE, Gandevia SC (2000) Changes in muscle afferents, motoneurons and motor drive during muscle fatigue. Eur J Appl Physiol 83(2–3):106–115

    Article  CAS  PubMed  Google Scholar 

  4. Boot CR, Groothuis JT, Van Langen H, Hopman MT (1985) Shear stress levels in paralyzed legs of spinal cord-injured individuals with and without nerve degeneration. J Appl Physiol 92(6):2335–2340

    Google Scholar 

  5. Larsson R, Oberg PA, Larsson SE (1999) Changes of trapezius muscle blood flow and electromyography in chronic neck pain due to trapezius myalgia. Pain 79(1):45–50

    Article  CAS  PubMed  Google Scholar 

  6. Mijailovich SM, Fredberg JJ, Butler JP (1996) On the theory of muscle contraction: filament extensibility and the development of isometric force and stiffness. Biophys J 71(3):1475–1484

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Meythaler JM, McCary A, Hadley MN (1996) Intrathecal baclofen for spastic hypertonia in adult brain injury. Perspect Neurosurg 7:99–107

    Google Scholar 

  8. Chou R, Peterson K, Helfand M (2004) Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage 28(2):140–175

    Article  CAS  PubMed  Google Scholar 

  9. Hulme A, MacLennan WJ, Ritchie RT, John VA, Shotton PA (1985) Baclofen in the elderly stroke patient its side-effects and pharmacokinetics. Eur J Clin Pharmacol 29(4):467–469

    Article  CAS  PubMed  Google Scholar 

  10. Kolaski K, Logan LR (2007) A review of the complications of intrathecal baclofen in patients with cerebral palsy. Neuro Rehabil 22(5):383–395

    Google Scholar 

  11. Lennon S (1996) The Bobath concept: a critical review of the theoretical assumptions that guide physiotherapy practice in stroke rehabilitation. Phys Ther Rev 1(1):35–45

    Article  Google Scholar 

  12. Naghdi S, Ansari NN, Mansouri K, Hasson S (2010) A neurophysiological and clinical study of Brunnstrom recovery stages in the upper limb following stroke. Brain Inj 24(11):1372–1378

    Article  PubMed  Google Scholar 

  13. Bjordal JM, Couppé C, Chow RT, Tunér J, Ljunggren EA (2003) A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother 49(2):107–116

    Article  PubMed  Google Scholar 

  14. Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes-Martins RA (2006) Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 24(2):158–168

    Article  CAS  PubMed  Google Scholar 

  15. Conlan MJ, Rapley JW, Cobb CM (1996) Biostimulation of wound healing by low-energy laser irradiation: a review. J Clin Periodontol 23(5):492–496

    Article  CAS  PubMed  Google Scholar 

  16. Hayworth CR, Rojas JC, Padilla E, Holmes GM, Sheridan EC, Gonzalez-Lima F (2010) In vivo low-level light therapy increases cytochrome oxidase in skeletal muscle. Photochem Photobiol 86(3):673–680

    Article  CAS  PubMed  Google Scholar 

  17. Gür A, Karakoç M, Nas K, Cevik R, Saraç J, Demir E (2002) Efficacy of low power laser therapy in fibromyalgia: a single-blind, placebo-controlled trial. Lasers Med Sci 17(1):57–61

    Article  PubMed  Google Scholar 

  18. Monici M, Cialdai F, Fusi F, Romano G, Pratesi R (2008) Effects of pulsed Nd:YAG laser at molecular and cellular level. Energy Health 3:26–32

    Google Scholar 

  19. Baggish MS (1980) High-power–density carbon dioxide laser therapy for early cervical neoplasia. Am J Obstet Gynecol 136(1):117–125

    CAS  PubMed  Google Scholar 

  20. Stiglić-Rogoznica N, Stamenković D, Frlan-Vrgoc L, Avancini-Dobrović V, Vrbanić TS (2011) Analgesic effect of high intensity laser therapy in knee osteoarthritis. Coll Antropol 35(2):183–185

    PubMed  Google Scholar 

  21. Hamaoka T, McCully KK, Niwayama M, Chance B (1955) The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments. Philos Trans R Soc A Math Phys Eng Sci 369:4591–4604

    Article  Google Scholar 

  22. Bhambhani Y, Tuchak C, Burnham R, Jeon J, Maikala R (2000) Quadriceps muscle deoxygenation during functional electrical stimulation in adults with spinal cord injury. Spinal Cord 38(10):630–638

    Article  CAS  PubMed  Google Scholar 

  23. Johns M, Giller CA, Liu H (2001) Determination of hemoglobin oxygen saturation from turbid media using reflectance spectroscopy with small source-detector separations. Appl Spectrosc 55(12):1686–1694

    Article  CAS  Google Scholar 

  24. Benesch R, Macduff G, Benesch RE (1965) Determination of oxygen equilibria with a versatile new tonometer. Anal Biochem 11:81–87

    Article  CAS  PubMed  Google Scholar 

  25. van Assendelft OW, Zijlstra WG (1975) Extinction coefficients for use in equations for the spectrophotometric analysis of haemoglobin mixtures. Anal Biochem 69(1):43–48

    Article  PubMed  Google Scholar 

  26. Cope M (1991) The application of near infrared spectroscopy to noninvasive monitoring of cerebral oxygenation in the newborn infant. Dissertation, University of London

  27. Huguenin LK (2004) Myofascial trigger points: the current evidence. Phys Ther Sport 5(1):2–12

    Article  Google Scholar 

  28. Chance B, Dait MT, Zhang C, Hamaoka T, Hagerman F (1992) Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers. Am J Physiol 262:766–775

    Google Scholar 

  29. Yu G, Durduran T, Lech G, Zhou C, Chance B, Mohler ER 3rd, Yodh AG (2005) Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies. J Biomed Opt 10(2):024027

    Article  PubMed  Google Scholar 

  30. Binzoni T, Cooper CE, Wittekind AL, Beneke R, Elwell CE, Van De Ville D, Leung TS (2010) A new method to measure local oxygen consumption in human skeletal muscle during dynamic exercise using near-infrared spectroscopy. Physiol Meas 31(9):1257–1269

    Article  PubMed  Google Scholar 

  31. Steel WH (1985) Interferometry, 2nd edn. Cambridge University Press, Cambridge

    Google Scholar 

  32. Stiglić-Rogoznica N, Stamenković D, Frlan-Vrgoc L, Avancini-Dobrović V, Vrbanić TS (2011) Analgesic effect of high intensity laser therapy in knee osteoarthritis. Coll Antropol 35:183–185

    PubMed  Google Scholar 

  33. Zati A, Degli Esposti S, Bilotta TW (1997) Analgesic and psychological effects of CO2 Laser treatment: a clinical study. Laser Technol 7:23–30

    Google Scholar 

  34. Kujawa J, Zavodnik L, Zavodnik I, Buko V, Lapshyna A, Bryszewska M (2004) Effect of low-intensity (3.75-25 J/cm2) near-infrared (810 nm) laser radiation on red blood cell ATPase activities and membrane structure. J Clin Laser Med Surg 22(2):111–117

    Article  PubMed  Google Scholar 

  35. Santamato A, Solfrizzi V, Panza F, Tondi G, Frisardi V, Leggin BG, Ranieri M, Fiore P (2009) Short-term effects of high-intensity laser therapy versus ultrasound therapy in the treatment of people with subacromial impingement syndrome: a randomized clinical trial. Phys Ther 89(7):643–652

    Article  PubMed  Google Scholar 

  36. Dhindsa MS, Merring CA, Brandt LE, Tanaka H, Griffin L (2011) Muscle spasticity associated with reduced whole-leg perfusion in persons with spinal cord injury. J Spinal Cord Med 34(6):594–599

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010–0008977, 2010–0029468) and a grant of the Traditional Korean Medicine R&D Project, Ministry for Health & Welfare & Family Affairs, Republic of Korea (B110010).

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Neuroscience, College of Oriental Medicine, Wonkwang University, Iksan, 570-749, South Korea

    Sangkwan Lee

  2. Department of Biomedical Engineering, College of Medical Science, Catholic University of Daegu, Gyeongsan, 712-702, South Korea

    Tae-Hoon Kim & Jong-In Youn

Authors
  1. Sangkwan Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tae-Hoon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jong-In Youn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jong-In Youn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, S., Kim, TH. & Youn, JI. Development of the theragnostic optical system for a high-intensity laser therapy (HILT). Lasers Med Sci 29, 1585–1591 (2014). https://doi.org/10.1007/s10103-014-1559-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-014-1559-7

Keywords

Search

Navigation