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Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation

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Abstract

This randomized controlled clinical trial was designed to evaluate the efficacy of single-session, non-thermal, carbon dioxide (CO2) laser irradiation in relieving the pain of minor recurrent aphthous stomatitis (miRAS) as a prototype of painful oral ulcers. Fifteen patients, each with two discrete aphthous ulcers, were included. One of the ulcers was randomly allocated to be treated with CO2 laser (1 W of power in de-focused continuous mode) and the other one served as a placebo. Before laser irradiation, a layer of transparent, non-anesthetic gel was placed on both the laser lesions and the placebo lesions. The patients were requested to grade their pain on a visual analog scale up to 96 h post-operatively. The reduction in pain scores was significantly greater in the laser group than in the placebo group. The procedure itself was not painful, so anesthesia was not required. Powermetry revealed the CO2 laser power to be 2–5 mW after passing through the gel, which caused no significant temperature rise or any visual effect of damage to the oral mucosa. Our results showed that a low-intensity, non-thermal, single-session of CO2 laser irradiation reduced pain in miRAS immediately and dramatically, with no visible side effects.

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Acknowledgments

This study was funded by the research deputy of the Academic Center for Education, Culture and Research (no. 1139–10).

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Authors and Affiliations

  1. Iranian Center for Medical Laser (ICML), Academic Center for Education, Culture and Research (ACECR), 85 Nazari Alley, Abourihan Street, Enqelab Avenue, Tehran, Iran

    Nasrin Zand, Leila Ataie-Fashtami, Gholamreza Esmaeeli Djavid, Mohsen Fateh & Seyyed-Mostafa Fatemi

  2. Research Center of Science and Technology in Medicine (RCSTIM), Medical Sciences/University of Tehran, Tehran, Iran

    Mohammad-Reza Alinaghizadeh

  3. Department of Oral Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Fateme Arbabi-Kalati

Authors
  1. Nasrin Zand
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  2. Leila Ataie-Fashtami
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  3. Gholamreza Esmaeeli Djavid
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  4. Mohsen Fateh
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  5. Mohammad-Reza Alinaghizadeh
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  6. Seyyed-Mostafa Fatemi
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  7. Fateme Arbabi-Kalati
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Correspondence to Nasrin Zand.

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Zand, N., Ataie-Fashtami, L., Djavid, G.E. et al. Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci 24, 515–520 (2009). https://doi.org/10.1007/s10103-008-0555-1

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  • DOI: https://doi.org/10.1007/s10103-008-0555-1

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