Abstract
We have recently used Q-switched alexandrite laser for the treatment of various kinds of pigmented skin lesions. We retrospectively compared therapeutic outcomes of 153 Japanese patients who consulted our department. This approach was not very efficient for nevus spilus/café-au-lait spots, which seemed laser-resistant, especially when the pigmentation had appeared after 1 year of age, was treated after 5 years of age, was located on the face, was oval with a smooth border, and the patient was male. This approach was equally effective for senile lentigo, nevus of Ota, and Mongolian spots, but less effective for acquired bilateral nevus of Ota-like macules. Some patients with sacral Mongolian spots or those with light-colored, senile lentigo developed severe post-inflammatory hyperpigmentation after treatment. As a whole, good therapeutic outcome was achieved after multiple treatment sessions. However, the use of other lasers or other treatment modalities should be considered to treat nevus spilus/café-au-lait spots.
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References
Anderson RR, Parrish JA (1981) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527
Anderson RR, Parrish JA (1981) The optics of human skin. J Invest Dermatol 77:13–19
Grevelink JM, Gonzalez S, Bonoan R, Vibhagool C, Gonzalez E (1997) Treatment of nevus spilus with the Q-switched ruby laser. Dermatol Surg 23:365–369
Suzuki H, Anderson RR (2005) Treatment of melanocytic nevi. Dermatol Ther 18:217–226
Moreno-Arias GA, Bulla F, Vilata-Corell JJ, Camps-Fresneda A (2001) Treatment of widespread segmental nevus spilus by Q-switched alexandrite laser (755 nm, 100 nsec). Dermatol Surg 27:841–843
Moreno Arias GA, Ferrando J (2001) Intense pulsed light for melanocytic lesions. Dermatol Surg 27:397–400
Yoshimura K, Harii K, Aoyama T, Iga T (2000) Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals. Plast Reconstr Surg 105:1097–1108
Yamashita Y, Tamura T, Endoh H, Isogai R, Tezuka T (1998) Effectiveness of laser irradiation combined with topical application of 5% hydroquinone monobennzyl ether cream in treatment of café au lait macules. Skin Res 40:301–305 (Japanese)
Mackie RM (1998) Melanocytic naevi and malignant melanoma. In: Champion RH, Burton JL, Burns DA, Breathnach SM (eds) Textbook of dermatology, 6th edn. Blackwell Science, Oxford, pp 1717–1752
Mosher DB, Fitzpatrick TB, Ortonne J-P, Hori Y (1987) Disorders of pigmentation. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds) Dermatology in general medicine: textbook and atlas, 3rd edn. Vol 1. McGraw-Hill, New York, pp 854–856
Morooka K (1930) On the Mongolian spots in the Japanese. Acta Anat Jpn 3:1371–1490 (Japanese)
Kikuchi I, Inove S (1980) Natural history of the Mongolian spot. J Dermatol 7:449–450
Hidano A (1971) Persistent Mongolian spot in the adult. Arch Dermatol 103:680–681
Kikuchi I (1980) Mongolian spots remaining in schoolchildren. J Dermatol 7:213–216
Ashrafi MR, Shabanian R, Mohammadi M, Kavusi S (2006) Extensive Mongolian spots: a clinical sign merits special attention. Pediatr Neurol 34:143–145
Lee B, Kim YC, Kang WH, Lee ES (2004) Comparison of characteristics of acquired bilateral nevus of Ota-like macules and nevus of Ota according to therapeutic outcome. J Korean Med Sci 19:554–559
Chan HH, Kono T (2004) The use of lasers and intense pulsed light sources for the treatment of pigmentary lesions. Skin Ther Lett 9:5–7
Ohshiro T, Ohshiro T, Sasaki K, Fujii S (2006) Nevus spilus. Pepars 7:23–28 (Japanese)
Lam AY, Wong DS, Lam LK, Ho WS, Chan HH (2001) A retrospective study on the efficacy and complications of Q-switched alexandrite laser in the treatment of acquired bilateral nevus of Ota-like macules. Dermatol Surg 27:937–941
Chan HH, Lam LK, Wong DS, Leung RS, Ying SY, Lai CF, Ho WS, Chua JK (2001) Nevus of Ota: a new classification based on the response to laser treatment. Lasers Surg Med 28:267–272
Rho NK, Kim WS, Lee DY, Yang JM, Lee ES, Lee JH (2004) Histopathological parameters determining lesion colours in the naevus of Ota: a morphometric study using computer-assisted image analysis. Br J Dermatol 150:1148–1153
Kono T, Chan HH, Ercocen AR, Kikuchi Y, Uezono S, Iwasaka S, Isago T, Nozaki M (2003) Use of Q-switched ruby laser in the treatment of nevus of Ota in different age groups. Lasers Surg Med 32:391–395
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Kagami, S., Asahina, A., Watanabe, R. et al. Treatment of 153 Japanese patients with Q-switched alexandrite laser. Lasers Med Sci 22, 159–163 (2007). https://doi.org/10.1007/s10103-006-0436-4
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DOI: https://doi.org/10.1007/s10103-006-0436-4