Abstract
An expeditious and solvent-free approach for selective organic synthesis is described which involves simple exposure of neat reactants to microwave (MW) irradiation. The coupling of MW irradiation with the use of catalysts or mineral supported reagents, under solvent-free conditions, provides clean chemical processes with special attributes such as enhanced reaction rates, higher yields, greater selectivity and the ease of manipulation. Our recent results on this eco-friendly approach utilizing recyclable inorganic oxides or supported reagents such as Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH4NO3-clay (clayan), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, CrO3-alumina, MnO2-silica, and NaBH4-clay etc. are exemplified in MW-assisted deprotection, condensation, cyclization, oxidation and reduction reactions including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates.
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Received: 20 October 1998 / Accepted: 27 December 1998
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Varma, R. Solvent-free organic syntheses on mineral supports using microwave irradiation. Clean Products and Processes 1, 132–147 (1999). https://doi.org/10.1007/s100980050018
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DOI: https://doi.org/10.1007/s100980050018