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Emergence, Mechanism, and Clinical Implications of Reduced Glycopeptide Susceptibility in Staphylococcus aureus

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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract.

In order to understand the mechanism(s) of the resistance/reduced susceptibility of Staphylococcus aureus to glycopeptide antibiotics, the current data on the modes of action of glycopeptides were reviewed. In addition, the different test systems for detecting vancomycin resistance and the clinical relevance of resistant Staphylococcus aureus were analyzed. Finally, strategies to prevent the nosocomial spread of these bacteria are presented, as are new therapeutic options.

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Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Virologie der Heinrich Heine Universität Düsseldorf, Universitätsstraße 1, Gebaüde 22.21, 40225 Düsseldorf, Germany, Germany

    R. Geisel & F. Schmitz

  2. Institute of Medical Microbiology, Utrecht University Medical Center, Utrecht, The Netherlands, The Netherlands

    A. Fluit

  3. Bayer AG, PH-Research Antiinfectives, Wuppertal, Germany, Germany

    H. Labischinski

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  1. R. Geisel
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  2. F. Schmitz
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  3. A. Fluit
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  4. H. Labischinski
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Geisel, R., Schmitz, F., Fluit, A. et al. Emergence, Mechanism, and Clinical Implications of Reduced Glycopeptide Susceptibility in Staphylococcus aureus . Eur J Clin Microbiol Infect Dis 20, 685–697 (2001). https://doi.org/10.1007/s100960100595

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  • DOI: https://doi.org/10.1007/s100960100595

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