Immunorestitution Diseases in Patients not Infected with HIV

Abstract

 The aim of this study was to assess the clinical spectrum of immunorestitution disease (IRD) in hospitalized patients over a 12-month period. In nine of 18 patients who presented with clinical deterioration during reduction or cessation of immunosuppressants (n=6) or bone marrow engraftment (n=3), IRD cases included the following infections: scabies infestation (n=1); gastric strongyloidiasis (n=1); hepatosplenic candidiasis (n=1); methicillin-resistant Staphylococcus aureus abscess formation (n=2); polyomavirus-related hemorrhagic cystitis (n=3); and influenza A pneumonitis (n=1). Immunopathological damage during withdrawal of immunosuppression is an incidental way to uncover an asymptomatic infectious disease. Serial monitoring of hematological and clinical profiles is essential in making a diagnosis of IRD.