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High Prevalence of GB Virus C/Hepatitis G Virus RNA and Antibodies in Patients Infected with Human Immunodeficiency Virus Type 1

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Abstract

 The prevalence of GB virus C (GBV-C)/ hepatitis G virus (HGV) RNA and antibodies to the structural E2 protein was investigated in a cohort of HIV-1 infected patients. Of 346 individuals, RNA was detected in 143 and E2 antibodies were detected in 73, for an overall prevalence of 62.4%. Intravenous drug use and homosexuality were identified as major transmission risk factors. GBV-C/HGV RNA prevalence was associated with hepatitis B coinfection, whereas antibodies to E2 were associated with older age and lower CD4+ cell counts. GBV-C/HGV infection was frequent in this group of HIV-infected patients and was associated with older age, lower CD4+ cell counts, and the presence of hepatitis B surface antigen.

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Authors and Affiliations

  1. CISIH, Clinique Médicale A, Hôpitaux Universitaires, 1 place de l'Hôpital, 67091 Strasbourg Cedex, France e-mail: david.rey@chru-strasbourg.fr, , , , , , FR

    D. Rey & J. M. Lang

  2. Institut de Virologie, Faculté de Médecine, 3 rue Koeberlé, 67000 Strasbourg, France, , , , , , FR

    J. Vidinic-Moularde, C. Schmitt, S. Fritsch & F. Stoll-Keller

  3. Département d'Information Médicale, Hôpitaux Universitaires, 1 place de l'Hôpital, 67091 Strasbourg Cedex, France, , , , , , FR

    P. Meyer

Authors
  1. D. Rey
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  2. J. Vidinic-Moularde
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  3. P. Meyer
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  4. C. Schmitt
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  5. S. Fritsch
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  6. J. M. Lang
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  7. F. Stoll-Keller
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Rey, D., Vidinic-Moularde, J., Meyer, P. et al. High Prevalence of GB Virus C/Hepatitis G Virus RNA and Antibodies in Patients Infected with Human Immunodeficiency Virus Type 1. EJCMID 19, 721–724 (2000). https://doi.org/10.1007/s100960000352

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  • DOI: https://doi.org/10.1007/s100960000352

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