Abstract
In clinical practice, PTB patients have concurrent many types of comorbidities such as pneumonia, liver disorder, diabetes mellitus, hematological disorder, and malnutrition. Detecting and treating specific comorbidities and preventing their development are important for PTB patients. However, the prevalence of most comorbid conditions in patients with PTB is not well described. We conducted a large-scale, multicenter, observational study to elucidate and illustrate the prevalence rates of major comorbidities in inpatients at 21 hospitals in China. The 19 specific comorbidities were selected for analysis in this patient cohort, and stratified the inpatient cohort according to age and gender. A total of 355,929 PTB inpatients were included, with a male:female ratio of 1.98 and the proportion of ≥ 65 years PTB inpatients was the most. Approximately 70% of PTB inpatients had at least one defined type of comorbidity. The prevalence of 19 specific comorbidities in inpatients with PTB was analyzed, with pneumonia being the most common comorbidity. The prevalence of most comorbidities was higher in males with PTB except thyroid disorders, mental health disorders, etc. The prevalence of defined most comorbidities in patients with PTB tended to increase with increasing age, although some specific comorbidities tended to increase initially then decrease with increasing age. Our study describes multiple clinically important comorbidities among PTB inpatients, and their prevalence between different gender and age groups. The results will enhance the clinical aptitude of physicians who treat patients with PTB to recognize, diagnose, and treat PTB comorbidities early.
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Acknowledgments
We thank Vijay Harypursat, MBChB of Department of Infectious Disease, Chongqing Public Health Medical Center for his invaluable help editing the manuscript. We acknowledge the contributions from Innovation Alliance on Tuberculosis Diagnosis and Treatment (Beijing), and the doctors, laboratory technicians and nursing staff at the 21 hospitals in China involved in this study. This work was supported by Key Project of Chinese National Programs (Grant No. 2015ZX10003001), and ‘Beijing Municipal Administration of Hospitals’ Ascent Plan (No.DFL20181601), Tongzhou District development support plan for high-level talent (No.YHLD2019035) and Tongzhou District Science and Technology Committee [No.KJ2017CX054].
Funding
Key Project of Chinese National Programs (Grant No. 2015ZX10003001), ‘Beijing Municipal Administration of Hospitals’ Ascent Plan (No. DFL20181601), Tongzhou District development support plan for high-level talent (No.YHLD2019035) and Tongzhou District Science and Technology Committee [No.KJ2017CX054].
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TSJ, LL, and YXF designed the investigation. TSJ, LL,YXF, KWL, DJ, YS, CHY, LJX, MJS, LMW, QJM, SW, YJJ, ZPL, ZY, DYK, YZY, MZX, DQY, WP, HWG, WMY, CL, ZXG, TL, LFJ, ZC, LHW, LXJ, AET, DYR, LFL, CWY, WQH, CXH, HJF, XQY, FYM, LWY, TPJ, ZJY, ZJ, CDW, YXY, RT, LY, LYY, WL, SQ, YM, ZJ, LYY, GSL, YK, SXH, LD, and ZYL, participated in the implementation of the investigation. TSJ, LL, YXF, KWL, DJ, YS, CHY, LJX, MJS, LMW, QJM, SW, YJJ, ZPL, ZY, DYK, YZY, MZX, DQY, WP, HWG, WMY, CL, ZXG, TL, LFJ, ZC, LHW, LXJ, AET, DYR, LFL, CWY, WQH, CXH, HJF, XQY, FYM, LWY, TPJ, ZJY, ZJ, CDW, YXY, RT, LY, LYY, WL, SQ, YM, ZJ, LYY, GSL, YK, SXH, LD, and ZYL participated in data collection and data management. TSJ, LL, YXF, KWL, DJ, and YS participated in data analysis and wrote the initial draft of the report, and all authors revised and approved the final report.
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The research by ShenjieTang, Wanli Kang, Liang Li, Jian Du, et al. ‘The prevalence and risks of major co-morbidities among patients with pulmonary tuberculosis in China from a gender and age perspective: A large-scale multicenter observational study’ was studied on the data archived in our institute and ethics approval and consent was given by the medical ethics committee of Beijing Chest Hospital, Capital medical university. The need for informed consent was waived because this was an observational retrospective study, and all patient data were analyzed anonymously. The following reference number is (2018.4.16).
Medical ethics committee of Beijing Chest Hospital, Capital medical university.
Apr 16, 2018.
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The need for informed consent was waived because this was an observational retrospective study, and all patient data were analyzed anonymously.
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Kang, W., Du, J., Yang, S. et al. The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study. Eur J Clin Microbiol Infect Dis 40, 787–800 (2021). https://doi.org/10.1007/s10096-020-04077-2
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DOI: https://doi.org/10.1007/s10096-020-04077-2