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Serotype distribution of Streptococcus pneumoniae among healthy carriers and clinical patients: a systematic review from Iran

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A Correction to this article was published on 29 October 2020

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Abstract

Streptococcus pneumoniae is associated with high morbidity and mortality in the world. Commercially licensed and available pneumococcal conjugate vaccines (PCVs) contain 10 (PCV10) and 13 (PCV13) pneumococcal serotypes. The most common serotypes of S. pneumoniae causing clinical diseases and carriers of S. pneumoniae in Iran are not yet known. Reviewing and reporting trends in the distribution of pneumococcal serotypes in Iran will be useful for policy-making as PCV is being introduced into Iran’s routine immunization program. Here, we report a systematic literature review of studies regarding S. pneumoniae serotype distribution in clinical and carrier patients in Iran. MEDLINE (via PubMed), Scopus, Embase, Ovid, Google Scholar, Web of Science, and the Iranian Database were used to identify relevant papers published from 1 January 2000 to 21 August 2019. The search returned 8 relevant articles. Among serotypes causing invasive pneumococcal diseases (IPD), serotype 23F (16.4%) was the most circulating serotype followed by 19F (15.2%), 19A (11.3%), 6A/B (9.2%), 9 V (5.8%), and 11A (5.14%). In carrier patients, the most common serotypes were, in rank order, 6A/B (10%), 19F (9%), 14(6.2%), 17F (4.8%), and 20(4.5%). Vaccine coverage among IPD patients would be 67.1% for PCV10-TT and 73.8% for PCV13. The present review demonstrates that the serotypes which were most responsible for disease in Iran are included in PCV10-TT and PCV13. However, sentinel surveillance must be continued in representative parts of the country to assess changing trends in the distribution of pneumococcal serotypes and their implications for vaccine selection and rollout in Iran.

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Change history

  • 29 October 2020

    A correction to this paper has been published: https://doi.org/10.1007/s10096-020-04084-3.

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Acknowledgments

We thank K. Shashok (AuthorAID in the Eastern Mediterranean) for improving the use of English in the manuscript, Dr. Mohammadamin Joulani and Rasoul Akram Clinical Research Development Center (RCRDC) for its technical and editorial assists. This research was supported by grant no. 98-1-15-14930 from Student Research Committee, School of Medicine, Iran University of Medical Sciences.

Funding

This research was supported by grant no. 98-1-15-14930 from Student Research Committee, School of Medicine, Iran University of Medical Sciences.

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Authors and Affiliations

  1. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Maryam Alizadeh Chamkhaleh, Alireza Gandomi-Mohammadabadi, Javad Balasi & Hossein Abdiaei

  2. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

    Abdoulreza Esteghamati & Shirin Sayyahfar

  3. Department of Epidemiology, Iran University of Medical Sciences, Tehran, Iran

    Yousef Moradi

  4. Department of Community Medicine, Iran University of Medical Sciences and Health Services, Tehran, Iran

    Maziar Moradi-Lakeh

  5. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA

    Maziar Moradi-Lakeh

Authors
  1. Maryam Alizadeh Chamkhaleh
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  2. Abdoulreza Esteghamati
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  6. Hossein Abdiaei
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Correspondence to Abdoulreza Esteghamati.

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Ethical approval for this study was obtained from Iran University of Medical Sciences Ethics Committee (ID: IR.IUMS.REC.1398.748).

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The original online version of this article was revised: The name of the 6th author was incorrectly presented as Hossein Abdiae in the published article. The correct name is Hossein AbdiaeiIn the originally published article, the name of the 6th author was incorrectly presented as Hossein Abdiae. The correct name is Hossein Abdiaei.

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Alizadeh Chamkhaleh, M., Esteghamati, A., Sayyahfar, S. et al. Serotype distribution of Streptococcus pneumoniae among healthy carriers and clinical patients: a systematic review from Iran. Eur J Clin Microbiol Infect Dis 39, 2257–2267 (2020). https://doi.org/10.1007/s10096-020-03963-z

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