Skip to main content

Advertisement

SpringerLink
Log in

Time to positivity of follow-up blood cultures in patients with persistent Staphylococcus aureus bacteremia

  • Article
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

We investigated the clinical usefulness of time to blood culture positivity (TTP) of follow-up positive blood cultures (FUPBC) in patients with persistent Staphylococcus aureus bacteremia (SAB). Of the patients who did not have resolution of SAB after primary therapeutic intervention (PTI), patients who had decreases in TTP of FUPBC after PTI more frequently experienced 30-day mortality or secondary foci of infection than those who did not have decrease in TTP (83.3% vs. 28.6%; p = 0.005).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Khatib R, Riederer K, Saeed S, Johnson LB, Fakih MG, Sharma M, Tabriz MS, Khosrovaneh A (2005) Time to positivity in Staphylococcus aureus bacteremia: possible correlation with the source and outcome of infection. Clin Infect Dis 41:594–598

    Article  PubMed  Google Scholar 

  2. Kim J, Gregson DB, Ross T, Laupland KB (2010) Time to blood culture positivity in Staphylococcus aureus bacteremia: Association with 30-day mortality. J Infect 61:197–204

    Article  PubMed  Google Scholar 

  3. Lai CC, Wang CY, Liu WL, Huang YT, Hsueh PR (2011) Time to blood culture positivity as a predictor of methicillin resistance in Staphylococcus aureus bacteremia. J Infect 62:190–191

    Article  PubMed  Google Scholar 

  4. Marra AR, Edmond MB, Forbes BA, Wenzel RP, Bearman GML (2006) Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection. J Clin Microbiol 44:1342–1346

    Article  PubMed  Google Scholar 

  5. Liao CH, Huang YT, Chu FY, Lin TH, Hsueh PR (2008) Lack of increase in time to blood culture positivity in a patient with persistent methicillin-resistant Staphylococcus aureus bacteremia predicts failure of antimicrobial therapy. J Microbiol Immunol Infect 41:355–357

    PubMed  Google Scholar 

  6. Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Ryan T, Bashore T, Corey GR (2000) Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 30:633–638

    Article  PubMed  CAS  Google Scholar 

  7. Passerini R, Riggio D, Radice D, Bava L, Cassatella C, Salvatici M, Zorzino L, Sandri MT (2009) Interference of antibiotic therapy on blood cultures time-to-positivity: analysis of a 5-year experience in an oncology hospital. Eur J Clin Microbiol Infect Dis 28:95–98

    Article  PubMed  CAS  Google Scholar 

  8. Fowler VG, Sakoulas G, Mclntyre LM, Meka VG, Arbeit RD, Cabell CH, Stryjewski ME, Eliopoulos GM, Reller LB, Corey GR, Jones T, Lucindo N, Yeaman MR, Bayer AS (2004) Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis 190:1140–1149

    Article  PubMed  CAS  Google Scholar 

  9. Hawkins C, Huang J, Jin N, Noskin GA, Zembower TR, Bolon M (2007) Persistent Staphylococcus aureus bacteremia. Arch Intern Med 167:1861–1867

    Article  PubMed  Google Scholar 

  10. Khatib R, Johnson LB, Fakih MG, Riederer K, Khosrovaneh A, Tabriz MS, Sharma M, Saeed S (2006) Persistence in Staphylococcus aureus bacteremia: incidence, characteristics of patients and outcome. Scand J Infect Dis 38:7–14

    Article  PubMed  Google Scholar 

  11. Lin SH, Liao WH, Lai CC, Liao CH, Tan CK, Wang CY, Huang YT, Hsueh PR (2010) Risk factors for mortality in patients with persistent methicillin-resistant Staphylococcus aureus bacteraemia in a tertiary care hospital in Taiwan. J Antimicrob Chemother 65:1792–1798

    Article  PubMed  CAS  Google Scholar 

  12. Yoon YK, Kim JK, Park DW, Sohn JW, Kim MJ (2010) Predictors of persistent methicillin-resistant Staphylococcus aureus bacteraemia in patients treated with vancomycin. J Antimicrob Chemother 65:1015–1018

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

All authors report no conflicts.

Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 224-1 Heukseok-dong, Dongjak-gu, Seoul, 156-755, Republic of Korea

    S. H. Choi & J. W. Chung

Authors
  1. S. H. Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. W. Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. W. Chung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Choi, S.H., Chung, J.W. Time to positivity of follow-up blood cultures in patients with persistent Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis 31, 2963–2967 (2012). https://doi.org/10.1007/s10096-012-1648-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-012-1648-0

Keywords

Search

Navigation