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Impact of pneumococcal vaccines on invasive pneumococcal disease in Taiwan

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Abstract

In Taiwan, the 23-valent pneumococcal polysaccharide vaccine (PPV23) and the 7-valent pneumococcal conjugate vaccine (PCV7) have been available since January 2001 and October 2005, respectively. A hospital-based surveillance of invasive pneumococcal disease (IPD) in a medical center was conducted from 2000 to 2008 to evaluate the epidemiologic changes after pneumococcal vaccination. A total of 337 episodes in 328 patients were identified. The cumulative coverage rate of PPV23 among persons of age ≥75 years increased from 12% in 2007 to 41% in 2008, and that of PCV7 among children aged <5 years was 0.7% in 2005 and 25.2% in 2008. The annual incidence of IPD decreased from 6.2 cases per 10,000 hospitalizations in 2000–2005 to 3.8 cases in 2006–2008 (38.5% reduction, P < 0.001), but the fatality rate did not change significantly (24.4% and 21.8%, P = 0.74). The serotype coverage rates of PPV23 and PCV7 were not significantly different between 2000–2005 and 2006–2008 (both P > 0.05). A marked increase of serotype 19A from 2000–2005 (0.5%) to 2006–2008 (11.5%) was found (P < 0.001). In summary, a decline in IPD incidence but not in fatality rate occurred after the availability of PCV7 and the increased usage of PPV23. The rapid emergence of serotype 19A during this period is alarming.

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Authors’ disclosures of potential conflicts of interest

The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Family Medicine, Taipei County Hospital, Sanchong City, Taipei County, Taiwan

    W.-H. Liao

  2. Department of Internal Medicine, Taipei County Hospital, Sanchong City, Taipei County, Taiwan

    S.-H. Lin

  3. Department of Internal Medicine, Cardinal Tien Hospital, Xintien City, Taipei County, Taiwan

    C.-C. Lai & C.-Y. Wang

  4. Department of Intensive Care Medicine, Chi-Mei Medical Center, Tainan, Taiwan

    C.-K. Tan

  5. Department of Internal Medicine, Far Eastern Memorial Hospital, Banciao City, Taipei County, Taiwan

    C.-H. Liao

  6. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, 100, Taipei, Taiwan

    Y.-T. Huang & P.-R. Hsueh

Authors
  1. W.-H. Liao
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  2. S.-H. Lin
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  3. C.-C. Lai
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  4. C.-K. Tan
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  5. C.-H. Liao
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  6. Y.-T. Huang
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  7. C.-Y. Wang
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  8. P.-R. Hsueh
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Corresponding author

Correspondence to P.-R. Hsueh.

Additional information

Wan-Hsiu Liao and Sheng-Hsiang Lin contributed equally to this work.

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Liao, WH., Lin, SH., Lai, CC. et al. Impact of pneumococcal vaccines on invasive pneumococcal disease in Taiwan. Eur J Clin Microbiol Infect Dis 29, 489–492 (2010). https://doi.org/10.1007/s10096-010-0873-7

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  • DOI: https://doi.org/10.1007/s10096-010-0873-7

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