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Isolation of Corynebacterium ureicelerivorans from normally sterile sites in humans

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Abstract

Fifteen Corynebacterium ureicelerivorans isolates were recovered in pure culture from six patients during a five-year period. Five patients had bacteremia and the other was an infection of ascitic fluid. The API Coryne™ numerical profile obtained corresponds to the profile for C. bovis, while Biolog™ GP2 identified four out of the six isolates as C. jeikeium. The organisms were molecular identified by 16S rDNA and rpoB. The present report also includes information on new phenotypic tests and, for the first time, antimicrobial susceptibility data of C. ureicelerivorans and their rpoB sequences. All macrolide-resistant isolates presented a constitutive MLS phenotype. This organism must be differentiated from other slow-growing, lipophilic, and urea-splitting corynebacteria.

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References

  1. Yassin AF (2007) Corynebacterium ureicelerivorans sp. nov., a lipophilic bacterium isolated from blood culture. Int J Syst Evol Microbiol 57:1200–1203

    Article  PubMed  CAS  Google Scholar 

  2. Bernard KA, Munro C, Wiebe D, Ongsansoy E (2002) Characteristics of rare or recently described Corynebacterium species recovered from human clinical material in Canada. J Clin Microbiol 40:4375–4381

    Article  PubMed  CAS  Google Scholar 

  3. Renaud FN, Dutaur M, Daoud S, Aubel D, Riegel P, Monget D, Freney J (1998) Differentiation of Corynebacterium amycolatum, C. minutissimum, and C. striatum by carbon substrate assimilation tests. J Clin Microbiol 36:3698–3702

    PubMed  CAS  Google Scholar 

  4. Funke G, Bernard KA (2007) Coryneform gram-positive rods. In: Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA (eds) Manual of clinical microbiology, 9th edn. American Society for Microbiology, Washington, DC, pp 485–514

    Google Scholar 

  5. Lindenmann K, von Graevenitz A, Funke G (1995) Evaluation of the Biolog system for the identification of asporogenous, aerobic Gram-positive rods. Med Microbiol Lett 4:287–296

    Google Scholar 

  6. Khamis A, Raoult D, La Scola B (2005) Comparison between rpoB and 16S rRNA gene sequencing for molecular identification of 168 clinical isolates of Corynebacterium. J Clin Microbiol 43:1934–1936

    Article  PubMed  CAS  Google Scholar 

  7. Seppälä H, Nissinen A, Yu Q, Huovinen P (1993) Three different phenotypes of erythromycin-resistant Streptococcus pyogenes in Finland. J Antimicrob Chemother 32:885–891

    Article  PubMed  Google Scholar 

  8. Funke G, Lawson PA, Collins MD (1997) Corynebacterium mucifaciens sp. nov., an unusual species from human clinical material. Int J Syst Bacteriol 47:952–957

    Article  PubMed  CAS  Google Scholar 

  9. Cantarelli VV, Brodt TC, Secchi C, Inamine E, Pereira Fde S, Pilger DA (2006) Fatal case of bacteremia caused by an atypical strain of Corynebacterium mucifaciens. Braz J Infect Dis 10:416–418

    Article  PubMed  Google Scholar 

  10. Clinical and Laboratory Standards Institute (CLSI) (2007) Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; approved guideline. CLSI document M45-A (ISBN 1-56238-607-7). CLSI, Wayne, Pennsylvania

  11. Yassin AF, Steiner U, Ludwig W (2002) Corynebacterium appendicis sp. nov. Int J Syst Evol Microbiol 52:1165–1169

    Article  PubMed  CAS  Google Scholar 

  12. Soriano F, Tauch A (2008) Microbiological and clinical features of Corynebacterium urealyticum: urinary tract stones and genomics as the Rosetta Stone. Clin Microbiol Infect 14:632–643

    Article  PubMed  CAS  Google Scholar 

  13. Soriano F, Fernández-Roblas R, Calvo R, García-Calvo G (1998) In vitro susceptibilities of aerobic and facultative non-spore-forming gram-positive bacilli to HMR 3647 (RU 66647) and 14 other antimicrobials. Antimicrob Agents Chemother 42:1028–1033

    PubMed  CAS  Google Scholar 

  14. Funke G, Troxler R (2005) In vitro activity of quinupristin and dalfopristin in combination and alone against coryneform bacteria. Eur J Clin Microbiol Infect Dis 24:769–771

    Article  PubMed  CAS  Google Scholar 

  15. Fernández-Natal MI, Sáez-Nieto JA, Fernández-Roblas R, Asencio M, Valdezate S, Lapeña S, Rodríguez-Pollán RH, Guerra JM, Blanco J, Cachón F, Soriano F (2008) The isolation of Corynebacterium coyleae from clinical samples: clinical and microbiological data. Eur J Clin Microbiol Infect Dis 27:177–184

    Article  PubMed  Google Scholar 

  16. Funke G, Frodl R (2008) Comprehensive study of Corynebacterium freneyi strains and extended and emended description of Corynebacterium freneyi Renaud, Aubel, Riegel, Meugnier, and Bollet 2001. J Clin Microbiol 46:638–643

    Article  PubMed  Google Scholar 

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Acknowledgments

This study has been supported by the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Madrid, Spain, Research Project 03/0534.

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All authors: no conflicts.

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Authors and Affiliations

  1. Department of Clinical Microbiology, Complejo Asistencial de León, Sacyl, Altos de Nava s/n, 24071, León, Spain

    M. I. Fernández-Natal, R. H. Rodríguez-Pollán & F. Cachón

  2. Bacterial Taxonomy Laboratory, Servicio de Bacteriología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

    J. A. Sáez-Nieto & S. Valdezate

  3. Department of Pediatrics, Complejo Asistencial de León, León, Spain

    S. Lapeña

  4. Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz, Madrid, Spain

    F. Soriano

Authors
  1. M. I. Fernández-Natal
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  2. J. A. Sáez-Nieto
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  3. S. Valdezate
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  4. R. H. Rodríguez-Pollán
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  5. S. Lapeña
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  6. F. Cachón
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  7. F. Soriano
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Correspondence to M. I. Fernández-Natal.

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Fernández-Natal, M.I., Sáez-Nieto, J.A., Valdezate, S. et al. Isolation of Corynebacterium ureicelerivorans from normally sterile sites in humans. Eur J Clin Microbiol Infect Dis 28, 677–681 (2009). https://doi.org/10.1007/s10096-008-0677-1

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  • DOI: https://doi.org/10.1007/s10096-008-0677-1

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