Skip to main content

Advertisement

Log in

The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge

  • Brief Report
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Tarnvik A (1989) Nature of protective immunity to Francisella tularensis. Rev Infect Dis 11:440–451

    PubMed  CAS  Google Scholar 

  2. Dennis DT, Inglesby TV, Henderson DA et al (2001) Tularemia as a biological weapon: medical and public health management. JAMA 285:2763–2773

    Article  PubMed  CAS  Google Scholar 

  3. Titball RW, Johansson A, Forsman M (2003) Will the enigma of Francisella tularensis virulence soon be solved? Trends Microbiol 11:118–123

    Article  PubMed  CAS  Google Scholar 

  4. Elkins KL, Cowley SC, Bosio CM (2003) Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain. Microbes Infect 5:135–142

    Article  PubMed  CAS  Google Scholar 

  5. Lauriano CM, Barker JR, Yoon SS, Nano FE, Arulanandam BP, Hassett DJ, Klose KE (2004) MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc Natl Acad Sci USA 101:4246–4249

    Article  PubMed  CAS  Google Scholar 

  6. Pammit MA, Raulie EK, Lauriano CM, Klose KE, Arulanandam BP (2006) Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia. Infect Immun 74:2063–2071

    Article  PubMed  CAS  Google Scholar 

  7. Provenza MJ, Klotz SA, Penn RL (1986) Isolation of Francisella tularensis from blood. J Clin Microbiol 24:453–455

    PubMed  CAS  Google Scholar 

  8. Long GW, Oprandy JJ, Narayanan RB, Fortier AH, Porter KR, Nacy CA (1993) Detection of Francisella tularensis in blood by polymerase chain reaction. J Clin Microbiol 31:152–154

    PubMed  CAS  Google Scholar 

  9. Forestal CA, Malik M, Catlett SV, Savitt AG, Benach JL, Sellati TJ, Furie MB (2007) Francisella tularensis has a significant extracellular phase in infected mice. J Infect Dis 196:134–137

    Article  PubMed  Google Scholar 

  10. Forsman M, Sandstrom G, Sjostedt A (1994) Analysis of 16S ribosomal DNA sequences of Francisella strains and utilization for determination of the phylogeny of the genus and for identification of strains by PCR. Int J Syst Bacteriol 44:38–46

    Article  PubMed  CAS  Google Scholar 

  11. Edelson BT, Unanue ER (2001) Intracellular antibody neutralizes Listeria growth. Immunity 14:503–512

    Article  PubMed  CAS  Google Scholar 

  12. Li JS, Winslow GM (2003) Survival, replication, and antibody susceptibility of Ehrlichia chaffeensis outside of host cells. Infect Immun 71:4229–4237

    Article  PubMed  CAS  Google Scholar 

  13. Kirimanjeswara GS, Golden JM, Bakshi CS, Metzger DW (2007) Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis. J Immunol 179:532–539

    PubMed  CAS  Google Scholar 

  14. Stenmark S, Lindgren H, Tarnvik A, Sjostedt A (2003) Specific antibodies contribute to the host protection against strains of Francisella tularensis subspecies holarctica. Microb Pathog 35:73–80

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by National Institutes of Health grant PO1 AI057986. The authors thank Michael Pammit from UTSA for technical expertise.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. P. Arulanandam.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yu, JJ., Raulie, E.K., Murthy, A.K. et al. The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge. Eur J Clin Microbiol Infect Dis 27, 323–325 (2008). https://doi.org/10.1007/s10096-007-0434-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-007-0434-x

Keywords

Navigation