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Impact of hepatitis C virus coinfection on immune restoration during successful antiretroviral therapy in chronic human immunodeficiency virus type 1 disease

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Abstract

The effect of coinfection with hepatitis C virus (HCV) on immune restoration in 39 human immunodeficiency virus (HIV)-infected patients during treatment with combined antiretroviral therapy (cART) was prospectively evaluated. After 48 weeks of treatment, HCV-coinfected patients had lower increases in CD4% (P = .05), total CD4+ (P = .01), and naïve CD4+ (P = .06) T cells than did single-infected subjects. Higher baseline naïve CD4+ T-cell levels were associated with better CD4+ (P = .05) and naïve CD4+ (P < .001) T-cell recovery. After a 4-year follow up, the differences disappeared (median CD4+ increase: 291 and 306 cells for HCV-positive and HCV-negative patients, respectively, P = .9). No significant differences were seen in memory CD4+ T cells (P = .30), and CD8+ cells expressing CD38 (P = .10) and CD28 (P = .73). These results suggest that, independently of other factors, infection with HCV blunts early CD4+ T-cell recovery in HIV-infected patients treated with combined antiretroviral therapy (cART). However, as good control of viral replication is maintained, satisfactory long-term immune restoration can nonetheless be achieved.

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Acknowledgements

The authors thank Isaac Ruiz (Department of Infectious Diseases) for assistance with statistical analysis.

Previous presentation

This paper was presented in part at the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA, September 14–17, 2003. Title: Immune restoration and dynamics of hepatitis C virus (HCV)-RNA in HIV-HCV coinfected patients treated with HAART. (Abstract number: H-827). Financial support:

This study was funded by the Fundació “La Marató TV3” 2,000 [grant: 000910].

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Authors and Affiliations

  1. Department of Infectious Diseases, IDIBELL, Hospital Universitari de Bellvitge, University of Barcelona, C/ Feixa Llarga s/n, 08907, L’Hospitalet, Barcelona, Spain

    M. Santin, E. Shaw, M. J. Barbera, D. Podzamczer & F. Gudiol

  2. Department of Immunology, IDIBELL, Hospital Universitari de Bellvitge, University of Barcelona, C/ Feixa Llarga s/n, 08907, L’Hospitalet, Barcelona, Spain

    M. Mestre

  3. Department of Microbiology, IDIBELL, Hospital Universitari de Bellvitge, University of Barcelona, C/ Feixa Llarga s/n, 08907, L’Hospitalet, Barcelona, Spain

    A. Casanova & J. Niubo

  4. Department of Internal Medicine, IDIBELL, Hospital Universitari de Bellvitge, University of Barcelona, C/ Feixa Llarga s/n, 08907, L’Hospitalet, Barcelona, Spain

    F. Bolao

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  1. M. Santin
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  2. M. Mestre
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  9. F. Gudiol
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Correspondence to M. Santin.

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Santin, M., Mestre, M., Shaw, E. et al. Impact of hepatitis C virus coinfection on immune restoration during successful antiretroviral therapy in chronic human immunodeficiency virus type 1 disease. Eur J Clin Microbiol Infect Dis 27, 65–73 (2008). https://doi.org/10.1007/s10096-007-0384-3

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  • DOI: https://doi.org/10.1007/s10096-007-0384-3

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