Skip to main content

Advertisement

SpringerLink
Log in

Successful treatment of septic shock due to pan-resistant Acinetobacter baumannii using combined antimicrobial therapy including tigecycline

  • Concise Article
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Reported here is the case of a patient with septic shock due to multidrug-resistant Acinetobacter baumannii, which developed after complicated acute pancreatitis with intra-abdominal abscess. Treatment with colistin methanesulphonate and high doses of meropenem were initiated, but since shock persisted, tigecycline was added to the regimen, resulting in successful resolution of the infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Henwood CJ, Gatward T, Warner M, James D, Stockdale MW, Spence RP, Towner KJ, Livermore DM, Woodford N (2002) Antibiotic resistance among clinical isolates of Acinetobacter in the UK, and in vitro evaluation of tigecycline (GAR-936). J Antimicrob Chemother 49:479–487

    Article  PubMed  CAS  Google Scholar 

  2. Livermore DM (2004) The need for new antibiotics. Clin Microbiol Infect 10(Suppl 4):1–9

    Article  PubMed  Google Scholar 

  3. Garrison MW, Neumiller JJ, Setter SM (2005) Tigecycline: an investigational glycylcycline antimicrobial with activity against resistant gram-positive organisms. Clin Ther 27:12–22

    Article  PubMed  CAS  Google Scholar 

  4. Petersen PJ, Jacobus NV, Weiss WJ, Sum PE, Testa RT (1999) In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 43:738–744

    PubMed  CAS  Google Scholar 

  5. Pachon-Ibanez ME, Jimenez-Mejias ME, Pichardo C, Llanos AC, Pachon J (2004) Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem. Antimicrob Agents Chemother 48:4479–4481

    Article  PubMed  CAS  Google Scholar 

  6. Kuo LC, Teng LJ, Yu CJ, Ho SW, Hsueh PR (2004) Dissemination of a clone of unusual phenotype of pandrug-resistant Acinetobacter baumannii at a university hospital in Taiwan. J Clin Microbiol 42:1759–1763

    Article  PubMed  Google Scholar 

  7. Falagas ME, Kasiakou SK (2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis 40:1333–1341

    Article  PubMed  CAS  Google Scholar 

  8. Postier RG, Green SL, Klein SR, Ellis-Grosse EJ, Loh E, Tigecycline 200 Study Group (2004) Results of a multicenter, randomised, open-label efficacy and safety of two doses tigecycline for complicated skin and skin-structure infections in hospitalized patients. Clin Ther 26:704–714

    Article  PubMed  CAS  Google Scholar 

  9. Dartois N and the Tigecycline 305 CSSSI Study Group (2004) Results of a phase 3, double-blind, safety and efficacy study comparing tigecycline with vancomycin/aztreonam to treat complicated skin and skin structure infections. In: Program and abstracts of the 44th annual interscience conference on antimicrobial agents and chemotherapy (Washington). Abstract no. L-986

  10. Murray J, Wilson S, Klein S et al (2003) The clinical response to tigecycline in the treatment of complicated intra-abdominal infections in hospitalized patients, a phase 2 clinical trial. In: Program and abstracts of the 43rd annual interscience conference on antimicrobial agents and chemotherapy (Chicago). Abstract no. L-739

  11. Betriu C, Rodriguez-Avial I, Sanchez BA, Gomez M, Alvarez J, Picazo JJ; Spanish Group of Tigecycline (2002) In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain. Antimicrob Agents Chemother 46:892–895

    Article  PubMed  CAS  Google Scholar 

  12. Yoon J, Urban C, Terzian C, Mariano N, Rahal JJ (2004) In vitro double and triple synergistic activities of polymyxin B, imipenem, and rifampin against multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 48:753–757

    Article  PubMed  CAS  Google Scholar 

  13. Bratu S, Tolaney P, Karumudi U, Quale J, Mooty M, Nichani S, Landman D (2005) Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J Antimicrob Chemother 56:128–132

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Infectious Diseases Department, Erasme University Hospital, University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    F. S. Taccone & F. Jacobs

  2. Microbiology Department, Erasme University Hospital, University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    H. Rodriguez-Villalobos

  3. Digestive Surgery Department, Erasme University Hospital, University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    V. De Moor

  4. Department of Intensive Care, Erasme University Hospital, University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    D. De Backer & J.-L. Vincent

  5. Gastroenterology Department, Erasme University Hospital, University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    J. Deviere

Authors
  1. F. S. Taccone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Rodriguez-Villalobos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. De Backer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. De Moor
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Deviere
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J.-L. Vincent
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. Jacobs
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. Jacobs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taccone, F.S., Rodriguez-Villalobos, H., De Backer, D. et al. Successful treatment of septic shock due to pan-resistant Acinetobacter baumannii using combined antimicrobial therapy including tigecycline. Eur J Clin Microbiol Infect Dis 25, 257–260 (2006). https://doi.org/10.1007/s10096-006-0123-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-006-0123-1

Keywords

Search

Navigation