Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) continues to evolve. Thus far, efforts to control the spread of MRSA in the UK have failed, resulting in a great deal of public and political concern. New guidelines advocate a much more active "seek and destroy" policy, but the causes of the epidemic go back 30 years to the start of an extended period of disinvestment in the national health service. Consequently, a multifaceted approach is needed now, one that includes a huge investment in infrastructure and facilities for patient isolation, cleaning and disinfection of equipment, laboratory diagnosis of MRSA, antibiotic stewardship, and training of medical and nursing staff.
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References
Public Health Service (2004) The third year of regional and national analyses of the Department of Health’s mandatory MRSA surveillance scheme in England, April 2001–March 2004. Commun Dis Rep CDR Wkly 14:1–6
Gould IM, Dancer S, MacKenzie F (2004) Surveillance of antimicrobial resistance in Scotland (SARiS). SCIEH Wkly Rep 38:209–210
Whitby M, McLaws M, Berry G (2001) Risk of death from methicillin-resistant Staphylococcus aureus bacteraemia: a meta-analysis. Med J Aust 175:264–267
Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y (2003) Comparison of mortality associated with methicillin-resistant Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 36:53–59
Dancer SJ (2004) The real costs of MRSA. In: Gould IM, van der Meer JWM (eds) Antibiotic policies: theory and practice. Kluwer/Plenum, New York, pp 281–309
Huletsky A, Giroux R, Rossbach V, et al (2004) New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci. J Clin Microbiol 42:1875–1884
Royal College of Physicians of Edinburgh and the Royal College of Physicians and Surgeons of Glasgow (2005) Good practice guidelines for the hospital management of methicillin resistant Staphylococcus aureus. Scottish Infection Standards and Strategy Group. J R Coll Phys Edinb (in press)
Lancet JC, Grenet K, Armand-Lefevre L, et al (2005) High prevalence of carriage of methicillin-resistant Staphylococcus aureus at hospital admission in elderly patients: implications for infection control strategies. Infect Control Hosp Epidemiol 26:121–126
Davis KA, Stewart JJ, Crouch HK, Florez CC, Hospenthal DR (2004) Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 39:776–782
Dupeyron C, Campillo B, Bordes M, Faubert E, Richardet JP, Mangeney N (2002) A clinical trial of mupirocin in the eradication of methicillin-resistant Staphylococcus aureus nasal carriage in a digestive disease unit. J Hosp Infect 52:281–287
Geffers C, Farr BM (2003) Risk of transmission of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) from patients colonized with MRSA. Infect Control Hosp Epidemiol 26:114–115
Cooper BS, Stone SP, Kibbler CC, Cookson BD, Roberts JA, Medley GF, Duckworth G, Lai R, Elbrahim S (2004) Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systemic review of the literature. BMJ 329:533–538
Boyce JM, Potter-Bynoe G, Chenevert C, King T (1997) Environmental contamination due to methicillin-resistant Staphylococcus aureus: possible infection control implication. Infect Control Hosp Epidemiol 18:622–627
Marinella MA, Pierson C, Chenoweth C (1997) A potential source of nosocomial infection? Arch Intern Med 157:786–790
French GL, Otter JA, Shannon KP, Adams NMT, Watling D, Parks MJ (2004) Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination. J Hosp Infect 57:31–37
Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, et al (2005) Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet 365:295–304
Hanberger H, Monnet DL, Nilsson LE (2005) Intensive care unit. In: Gould IM, van der Meer JWM (eds) Antibiotic policies: theory and practice. Kluwer/Plenum, New York, pp 261–279
Lopez-Lozano J-M, Beyaert A, MacKenzie FM, Wilson R, Stuart D, Monnet D, Gould IM (2004) Effect of an intervention programme on the MRSA outbreak in Aberdeen Royal Infirmary. Clin Microbiol Infect 10:(Suppl 3):131
Pan A, Carnevale G, Catenazzi P, et al (2005) Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections: effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA. Infect Control Hosp Epidemiol 26:127–133
Monnet DL, MacKenzie FM, Lopez-Lozano JM, Beyaert A, Camacho M, Wilson R, Stuart D, Gould IM (2004) Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen 1996–2000. Emerg Infect Dis 10:1432–1441
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Gould, I.M. Control of methicillin-resistant Staphylococcus aureus in the UK. Eur J Clin Microbiol Infect Dis 24, 789–793 (2005). https://doi.org/10.1007/s10096-005-0060-4
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DOI: https://doi.org/10.1007/s10096-005-0060-4