Abstract.
In the last two years, the environmental theory on the aetiology of Parkinson disease has acquired new data. From an experimental point of view, a new model of parkinsonism induced by rotenone, a diffuse insecticide, has been proposed, and in vitro studies have provided proof that several pesticides stimulate the formation of α-synuclein fibrils (one of the principal constituents of Lewy bodies). Moreover, a meta-analysis of all case-control studies so far performed showed a positive, statistically significant association between pesticide exposure and PD. In this context, we are performing a cohort study on 5575 licensed pesticide users in the province of Viterbo. After 27 years of follow-up, 4788 subjects are still alive. The aim of this study is to measure the prevalence of Parkinson's disease in a large group of workers with theoretically increased risk.
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Correspondence to N. Vanacore
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Vanacore, N., Nappo, A., Gentile, M. et al. Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users. Neurol Sci 23 (Suppl 2), s119–s120 (2002). https://doi.org/10.1007/s100720200098
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DOI: https://doi.org/10.1007/s100720200098