Skip to main content

Advertisement

Log in

Efficacy of levetiracetam in patients with episodic ataxia type 2 caused by CACNA1A mutation: three case reports

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Strupp M, Zwergal A, Brandt T (2007) Episodic ataxia type 2. Neurotherapeutics 4(2):267–273

    Article  CAS  PubMed  Google Scholar 

  2. Strupp M, Kalla R, Claassen J, Adrion C, Mansmann U, Klopstock T, Freilinger T, Neugebauer H, Spiegel R, Dichgans M, Lehmann-Horn F, Jurkat-Rott K, Brandt T, Jen JC, Jahn K (2011) A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias. Neurology 77(3):269–275. https://doi.org/10.1212/WNL.0b013e318225ab07

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Van Bogaert P, Szliwowski H (1996) EEG findings in acetazolamide-responsive hereditary paroxysmal ataxia. Neurophysiol Clin 26(5):335–340

    Article  PubMed  Google Scholar 

  4. Rajakulendran S, Graves TD, Labrum RW, Kotzadimitriou D, Eunson L, Davis MB, Davies R, Wood NW, Kullmann DM, Hanna MG, Schorge S (2010) Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy. J Physiol 588(Pt 11):1905–1913. https://doi.org/10.1113/jphysiol.2009.186437

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mantuano E, Romano S, Veneziano L, Gellera C, Castellotti B, Caimi S, Testa D, Estienne M, Zorzi G, Bugiani M, Rajabally YA, Barcina MJ, Servidei S, Panico A, Frontali M, Mariotti C (2010) Identification of novel and recurrent CACNA1A gene mutations in fifteen patients with episodic ataxia type 2. J Neurol Sci 291(1–2):30–36. https://doi.org/10.1016/j.jns.2010.01.010

    Article  CAS  PubMed  Google Scholar 

  6. Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, Grody WW, Hegde M, Lyon E, Spector E, Voelkerding K, Rehm HL (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405–424. https://doi.org/10.1038/gim.2015.30

    Article  PubMed  PubMed Central  Google Scholar 

  7. Park J, Oh HM, Park HJ, Cho AR, Lee DW, Jang JH, Jang DH (2019) Usefulness of comprehensive targeted multigene panel sequencing for neuromuscular disorders in Korean patients. Mol Genet Genomic Med 7(10):e00947. https://doi.org/10.1002/mgg3.947

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kotagal V Acetazolamide-responsive ataxia. In: Seminars in neurology, 2012. vol 05. Thieme Medical Publishers, pp 533–537

  9. Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T (2004) Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine. Neurology 62(9):1623–1625

    Article  CAS  PubMed  Google Scholar 

  10. Surges R, Volynski KE, Walker MC (2008) Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther Adv Neurol Disord 1(1):13–24

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lee H, Jang DH, Jang JH, Kim T (2017) Effectiveness of levetiracetam in an acetazolamide-unresponsive patient with episodic ataxia type 2 by a novel CACNA1A nonsense mutation. Eur J Neurol 24(7):e43–e44. https://doi.org/10.1111/ene.13327

    Article  CAS  PubMed  Google Scholar 

  12. Kaido M, Furuta M, Nakamori M, Yuasa Y, Takahashi MP (2016) Episodic ataxia type 2 manifests as epileptiform electroencephalographic activity with no epileptic attacks in two family members. Rinsho Shinkeigaku 56(4):260–264. https://doi.org/10.5692/clinicalneurol.cn-000854

    Article  PubMed  Google Scholar 

  13. Cordeau JP (1959) Monorhythmic frontal delta activity in the human electroencephalogram: a study of 100 cases. Electroencephalogr Clin Neurophysiol 11:733–746. https://doi.org/10.1016/0013-4694(59)90113-0

    Article  CAS  PubMed  Google Scholar 

  14. Sutter R, Stevens RD, Kaplan PW (2013) Clinical and imaging correlates of EEG patterns in hospitalized patients with encephalopathy. J Neurol 260(4):1087–1098. https://doi.org/10.1007/s00415-012-6766-1

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

SN wrote the manuscript. TK supervised the project.

Corresponding author

Correspondence to Taewon Kim.

Ethics declarations

Ethical approval

The authors declare that these case reports has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki. Informed consent was obtained from the patients and The Institutional Review Board at Incheon St. Mary’s Hospital approved this case report.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Na, S., Kim, T. Efficacy of levetiracetam in patients with episodic ataxia type 2 caused by CACNA1A mutation: three case reports . Neurol Sci 42, 3897–3899 (2021). https://doi.org/10.1007/s10072-021-05368-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-021-05368-y

Navigation