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Anti-MOG-associated demyelinating disorders: two sides of the same coin

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Abstract

Background

Anti-myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are new emerging diseases with heterogeneous course, treatment, response, and prognosis.

Case report

We herein present 2 cases with antibodies to MOG, one with a cerebellar/brainstem monophasic syndrome which partially improved after treatment, and the other with an optic neuritis onset then relapsed with cortical encephalitis and presented a subsequent complete recovery. We further discuss elements possibly associated with disease heterogeneity and influencing treatment choices.

Conclusions

MOGAD is an extremely variable disease which can relapse and accumulate disability over time. An early diagnosis and correct timely treatment is fundamental to improve clinical outcome.

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Authors and Affiliations

  1. Multiple Sclerosis Center, “A. Cardarelli” Hospital, Naples, Italy

    Giorgia Teresa Maniscalco & Lia Allegorico

  2. Neurological Clinic and Stroke Unit, “A. Cardarelli” Hospital, Naples, Italy

    Giorgia Teresa Maniscalco, Gennaro Alfieri, Massimo Napolitano, Angelo Ranieri, Rosaria Renna, Giovanna Servillo & Valentino Manzo

  3. UOC Neurophysiopathology, “A. Cardarelli” Hospital, Naples, Italy

    Marianna Pezzella

  4. Neuroradiology Department, “A. Cardarelli” Hospital, Naples, Italy

    Elisa Capone

  5. Immunohematology and Transfusion Medicine, “A. Cardarelli” Hospital, Naples, Italy

    Lidia Altomare & Michele Spiniello

  6. Neurology Unit, Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy

    Sergio Ferrari & Sara Mariotto

Authors
  1. Giorgia Teresa Maniscalco
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  2. Lia Allegorico
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  13. Valentino Manzo
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  14. Sara Mariotto
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Correspondence to Giorgia Teresa Maniscalco.

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Maniscalco, G.T., Allegorico, L., Alfieri, G. et al. Anti-MOG-associated demyelinating disorders: two sides of the same coin. Neurol Sci 42, 1531–1534 (2021). https://doi.org/10.1007/s10072-020-04892-7

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  • DOI: https://doi.org/10.1007/s10072-020-04892-7

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