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Lipid profiles and their potential inflammatory effects in anti-N-methyl-D-aspartate receptor encephalitis

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Abstract

Background

Growing evidence suggests an association between dyslipidemia and autoimmune diseases. This study aimed to perform a preliminary analysis to investigate the role of lipid profiles in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and to preliminarily explore the potential inflammatory effects of lipids on this disease by analyzing the association of lipid profiles with different inflammatory markers.

Methods

This retrospective study consisted of 40 anti-NMDAR encephalitis patients and 74 healthy controls. Serum lipid profiles and different inflammatory markers were analyzed upon admission and at each follow-up. Lipid profiles were compared among subgroups of patients, which were divided according to clinical characteristics. Correlations between lipid profiles and different inflammatory markers were assessed.

Results

The results showed that lipid profiles were abnormal and were correlated with both disease severity and prognosis in patients with anti-NMDAR encephalitis. Correlations between lipid profiles and different inflammatory markers were observed. After 12 months of treatment, inflammatory markers changed with lipid profiles, and these changes were significantly correlated.

Conclusions

Lipid profiles are associated with pathogenesis and progression of anti-NMDAR encephalitis, and they are significantly correlated with different inflammatory markers, suggesting that the association of lipids with the disease might be influenced by the inflammatory response.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgments

The authors thank the participating patients, their families, and staff at the study site.

Funding

This study was supported by the National Natural Science Foundation of China (No. 8167050849).

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Authors and Affiliations

  1. Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China

    Fei Liu, Chunjuan Wang & Shougang Guo

  2. Department of Neurology, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China

    Fei Liu & Baojie Wang

  3. Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, 250021, Shandong, China

    Chunjuan Wang & Shougang Guo

  4. Department of Resident Trainint, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China

    Bingbing Zhang

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  1. Fei Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Fei Liu, Bao-jie Wang, and Bing-bing Zhang. The first draft of the manuscript was written by Fei Liu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shougang Guo.

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The authors declare that they have no conflict of interest.

Ethical approval

This retrospective study was approved by the Ethics Committee of the Shandong Provincial Hospital Affiliated to Shandong University and performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Informed written consent was obtained from patients or their representatives.

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Not applicable.

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All authors have approved the manuscript and agreed with submission to the Journal of Neurology.

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Written informed consent was obtained from all patients or their representatives.

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Liu, F., Wang, B., Wang, C. et al. Lipid profiles and their potential inflammatory effects in anti-N-methyl-D-aspartate receptor encephalitis. Neurol Sci 42, 2881–2890 (2021). https://doi.org/10.1007/s10072-020-04882-9

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  • DOI: https://doi.org/10.1007/s10072-020-04882-9

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