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Insight in frontotemporal dementia and progressive supranuclear palsy

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Abstract

Introduction

Progressive supranuclear palsy (PSP) and behavioural variant frontotemporal dementia – (bv-FTD) share common neuropsychological features except for online monitoring awareness. Therefore, the aim of our study is to explore if this assessment could be used in standard clinical practice.

Materials and methods

We retrospectively analyse 93 subjects (27 FTD, 25 PSP, 42 healthy controls). Neuropsychological and instrumental examinations were performed for each patient.

Results

FTD patients made fewer self-corrections than PSP patients despite a similar number of total errors. We also performed ROC curves: the area under the curve (AUC) is 0.79. A model for a logistic regression was also developed: the only significant predictor is the number of self-corrections (p = 0.004 β = 1244).

Discussion and conclusions

In conclusion, our findings show online awareness is more compromised in FTD patients than in PSP patients. This difference could be useful for making a differential diagnosis between the two diseases: for each extra point in number of self-corrections the probability of suffering from PSP increases by about three and a half times (OR 3.47).

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Neurological Clinic, Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy

    Andrea Plutino, Emanuele Camerucci, Valentina Ranaldi, Sara Baldinelli, Chiara Fiori, Mauro Silvestrini & Simona Luzzi

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  1. Andrea Plutino
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Correspondence to Andrea Plutino.

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Plutino, A., Camerucci, E., Ranaldi, V. et al. Insight in frontotemporal dementia and progressive supranuclear palsy. Neurol Sci 41, 2135–2142 (2020). https://doi.org/10.1007/s10072-020-04290-z

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