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Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis

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Abstract

Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, appears to result from the combination of genetic and environmental factors. Whether the rs2275294 polymorphism in the ZNF512B gene influences ALS risk is controversial. We meta-analysed the association between rs2275294 and ALS risk based on evidence published in the PubMed database. Five case–control studies involving 2559 patients with sporadic ALS and 5740 controls were analysed. Based on random-effects meta-analysis, the polymorphism rs2275294 was associated with increased risk of ALS disease in an allele model (C vs. T: OR 1.222, 95%CI 1.057 to 1.414, p = 0.007). The available evidence suggests that the ZNF512B polymorphism rs2275294 is associated with ALS risk. These results should be validated in large, well-designed studies, especially in non-Asian populations.

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Funding

This work was funded by the Major Clinical Disease Research Program from the Health and Family Planning Commission of Sichuan Province (17ZD011) and the Sichuan Key Project of Science and Technology (2010SZ0086).

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Author notes

  1. Pingping Ning, Xinglong Yang and Baiyuan Yang contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, People’s Republic of China

    Pingping Ning, Quanzhen Zhao, Hongyan Huang, Ran An, Yalan Chen, Fayun Hu & Yanming Xu

  2. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 295 Xi Change Road, Kunming, 650032, Yunnan Province, People’s Republic of China

    Xinglong Yang

  3. Department of Neurology, Seventh People’s Hospital of Chengdu, Chengdu, Sichuan Province, People’s Republic of China

    Baiyuan Yang

  4. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China

    Zhuping Xu

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  1. Pingping Ning
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  2. Xinglong Yang
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  3. Baiyuan Yang
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  7. Yalan Chen
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  8. Fayun Hu
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  9. Zhuping Xu
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  10. Yanming Xu
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Correspondence to Zhuping Xu or Yanming Xu.

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Ning, P., Yang, X., Yang, B. et al. Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis. Neurol Sci 39, 1261–1266 (2018). https://doi.org/10.1007/s10072-018-3411-5

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  • DOI: https://doi.org/10.1007/s10072-018-3411-5

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