Skip to main content

Advertisement

SpringerLink
Log in

Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome

  • Brief Communication
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8+ T, γδ T and CD4+ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Mrak RE, Griffin WS (2004) Trisomy 21 and the brain. J Neuropathol Exp Neurol 63:679–685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. de Hingh YC, van der Vossen PW, Gemen EF et al (2005) Intrinsic abnormalities of lymphocyte counts in children with down syndrome. J Pediatr 147:744–747

    Article  PubMed  Google Scholar 

  3. Bull MJ (2011) Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics 128:393–406

    Article  PubMed  Google Scholar 

  4. Kuitert PC, Abbink FC, Broers CJ et al (2014) Epstein–Barr virus infection with severe consequences. EBV, haemophagocytic lymphohistiocytosis and Hodgkin lymphoma with Down syndrome. Ned Tijdschr Geneeskd 158:A7608

    PubMed  Google Scholar 

  5. Ogawa K, Tanaka K, Ishii A et al (2001) A novel serum protein that is selectively produced by cytotoxic lymphocytes. J Immun 166:6404–6412

    Article  CAS  PubMed  Google Scholar 

  6. Hayano C, Koi H, Ogawa K et al (2002) Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. Am J Reprod Immun 48:57–62

    Article  Google Scholar 

  7. Kuepper M, Koester K, Bratke K et al (2004) Increase in Ksp37-positive peripheral blood lymphocytes in mild extrinsic asthma. Clin Exp Immunol 137:359–365

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Salemi M, Barone C, Romano C et al (2013) Pericentrin expression in Down’s syndrome. Neurol Sci 34:2023–2025

    Article  PubMed  Google Scholar 

  9. Romagnani S (2001) T-cell responses in allergy and asthma. Curr Opin Allergy Clin Immunol 1:73–78

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by funds obtained from the Italian Ministry of Health (Ricerca Corrente).

Author information

Authors and Affiliations

  1. IRCCS Associazione Oasi Maria SS Institute for Research on Mental Retardation and Brain Aging, Troina (EN), Italy

    Michele Salemi, Concetta Barone, Maria Concetta Morale, Salvatore Caniglia, Carmelo Romano, Maria Grazia Salluzzo, Rosanna G. Galati Rando, Alda Ragalmuto, Paolo Bosco & Corrado Romano

Authors
  1. Michele Salemi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Concetta Barone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Concetta Morale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Salvatore Caniglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carmelo Romano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria Grazia Salluzzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rosanna G. Galati Rando
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alda Ragalmuto
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Paolo Bosco
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Corrado Romano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michele Salemi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This study was approved by the Ethical Committee of the Research Institute “IRCCS Associazione Oasi Maria SS.”, Troina (EN), Italy. The Ethical Committee, chaired by Prof. Salvino Leone, approved the project on June 17, 2013 (Prot. N. CE2013/06/17).

Informed consent

Written informed consent was obtained for every subject.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salemi, M., Barone, C., Morale, M.C. et al. Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome. Neurol Sci 37, 793–795 (2016). https://doi.org/10.1007/s10072-016-2554-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-016-2554-5

Keywords

Search

Navigation