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The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke

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Abstract

Stroke is a multifactorial disease caused by the combination of certain risk factors and genetic factors. There are possible risk factors having important role in the pathogenesis of stroke. The most important environmental factors are cigarette smoking and oxidative stress which have different sources. GST (M1, T1, P1) have major roles in detoxification of the products of oxidative stress and they are polymorphic. DNA damages can also be repaired by repair enzymes such as OGG1 and XRCC1 which are highly polymorphic and have pivotal roles in repair systems. In the present study, we investigated that polymorphisms in genes involved in detoxification and DNA-repair pathways might modify the individual’s risk for ischemic stroke. Furthermore, the products of oxidative stress and antioxidant capacity were measured and the impact of gene polymorphism on them was evaluated. Our data showed that OGG1 Ser326Cys and XRCC1 Arg399Gln gene polymorphisms had impacts on the development of stroke.

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Acknowledgments

The authors would like to give special thanks to all participants. We wish also to thank Aslıhan Alhan for statistical analysis.

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Authors and Affiliations

  1. Clinics of Neurology, Ankara Numune Hospital, Ankara, Turkey

    Gürdal Orhan, Semra Öztürk Mungan & Esra Eruyar

  2. Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey

    Aylin Elkama & Bensu Karahalil

Authors
  1. Gürdal Orhan
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  2. Aylin Elkama
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  3. Semra Öztürk Mungan
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  4. Esra Eruyar
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  5. Bensu Karahalil
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Correspondence to Bensu Karahalil.

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Orhan, G., Elkama, A., Mungan, S.Ö. et al. The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke. Neurol Sci 37, 955–961 (2016). https://doi.org/10.1007/s10072-016-2524-y

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  • DOI: https://doi.org/10.1007/s10072-016-2524-y

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