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Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis

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Abstract

This study aimed to investigate whether paraoxonase 1 (PON1) Q192R and L55M polymorphisms are associated with susceptibility to amyotrophic lateral sclerosis (ALS). We conducted a meta-analysis of the associations between the PON1 Q192R and L55M polymorphisms and ALS. A total of 2,831 patients and 3,123 controls from eight studies of the PON1 Q192R polymorphism and seven studies of the PON1 L55M T polymorphism were considered for this study. Meta-analysis showed no association between ALS and the PON1 192R allele (OR = 1.052, 95 % CI = 0.923–1.207, p = 0.447), and the PON1 55M allele (OR = 1.015, 95 % CI = 0.884–1.164, p = 0.837) in all study subjects. Similarly, no association was found between ALS and the PON1 Q192R and L55M polymorphisms using recessive, dominant or homozygote contrast models. Stratification by ethnicity indicated no association between ALS and the PON1 192R allele (OR = 1.058, 95 % CI = 0.910–1.231, p = 0.464) and the PON1 55M allele (OR = 1.027, 95 % CI = 0.889–1.185, p = 0.721) in the European population. This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.

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This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi, Jong Dae Ji & Gwan Gyu Song

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  1. Young Ho Lee
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  2. Jae-Hoon Kim
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  3. Young Ho Seo
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Correspondence to Young Ho Lee.

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Lee, Y.H., Kim, JH., Seo, Y.H. et al. Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis. Neurol Sci 36, 11–20 (2015). https://doi.org/10.1007/s10072-014-1979-y

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  • DOI: https://doi.org/10.1007/s10072-014-1979-y

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