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Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study

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Abstract

To use DCE-magnetic resonance imaging (MRI) and diffusion-weighted imaging to evaluate the hyperbaric oxygen efficacy (HBO) in experimental traumatic brain injury (TBI). Forty-two rabbits were randomly divided into four groups: TBI, TBI + HBO, sham group, sham + HBO. The TBI + HBO and sham + HBO received a total of 10 HBO treatments within 7 days following TBI, and MRI was performed within a month after TBI. Functional assessments were performed pre-TBI, and at 1 and 30 days. In focal lesion area, Ktrans in TBI + HBO group was lower than TBI group at both acute and subacute phase (p < 0.05). ADC was higher in TBI + HBO group than TBI group at acute phase (p < 0.01), but lower at subacute phase (p < 0.05). In perifocal area, Ktrans were lower in TBI + HBO group than TBI group at acute phase (p < 0.01) after TBI. ADC was lower in the TBI + HBO group than in the TBI group at both acute and subacute phase (p < 0.01).The VCS was higher in TBI + HBO group than TBI group at 30 days (p < 0.05). HBO could improve the impaired BBB and cytotoxic edema after TBI and promote the recovery of neurofunction.

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Acknowledgments

This study is supported by the National Natural Science Foundation of China (Grant No. 81271540, No. 81000609).

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Authors and Affiliations

  1. Department of Radiology, The Sixth Affiliated People’s Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai, 200233, China

    Xiao-Er Wei, Yue-Hua Li, Ming-Hua Li & Wen-Bin Li

  2. Department of Hyperbaric Oxygen, The Sixth Affiliated People’s Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai, 200233, China

    Hui Zhao & Min Fu

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  1. Xiao-Er Wei
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  2. Yue-Hua Li
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  3. Hui Zhao
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Correspondence to Wen-Bin Li.

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Wei, XE., Li, YH., Zhao, H. et al. Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study. Neurol Sci 35, 295–302 (2014). https://doi.org/10.1007/s10072-013-1514-6

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  • DOI: https://doi.org/10.1007/s10072-013-1514-6

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