Abstract
The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson’s disease (PD), before and after l-Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after l-Dopa administration. Unified Parkinson’s Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after l-Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye tracker, previously described, which can be proposed as a possible tool for supporting the diagnosis of PD in association with levodopa test, as an add-on to the UPDRS score.
Similar content being viewed by others
References
Shibasaki H, Tsuji S, Kuroiwa Y (1979) Oculomotor abnormalities in Parkinson’s disease. Arch Neurol 36:360–364
Bares M, Bràzdil M, Kanovsky P et al (2003) The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients. Parkinsonism Relat Disord 9:14–139
Lekwuwa GU, Barnes GR, Collins CJS, Limousin P (1999) Progressive bradykinesia and hypokinesia of ocular pursuit in Parkinson’s disease. J Neurol Neurosurg Psychiatry 66:746–753
Hughes AJ, Daniel SE, Kilford L et al (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184
Brooks DJ (1997) PET and SPECT studies in Parkinson’s disease. In: Quinn NP (ed) Parkinsonism. Bailliere Tindall, London, pp 69–87
Eardley I, Quinn NP, Fowler CJ et al (1989) The value of urethral sphincter electromyography in the differential diagnosis of parkinsonism. Br J Urol 64:360–362
D’Costa DF, Sheehan LJ, Phillips PA et al (1995) The levodopa test in Parkinson’s disease. Age Ageing 24(3):210–212
Marino S, Sessa E, Di Lorenzo G, Lanzafame P (2007) Quantitative analysis of pursuit ocular movements in Parkinson’s disease by using video-based eye tracking system. Eur Neurol 58(4):193–197
Members of the UPDRS Development Committee, Fahn S, Elton RL (1987) Unified Parkinson’s disease rating scale. In: Fahn S, Marsed CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease. MacMillan Healthcare Information, Florham Park: pp 153–163
Anderson TJ, Heitger MH, Jones RD, Ardagh MW, Donaldson IM (2001) Oculomotor deficits after mild closed head injury. J Neurol Sci 187:S432
Rascol O, Claner M, Montastruc JL et al (1989) Abnormal ocular movements in Parkinson’s disease: evidence for involvement of dopaminergic mechanisms. Brain 112:1193–1214
Gibson JM, Pimlott R, Kennard C (1987) Ocular motor and manual tracking in Parkinson’s disease and the effect of treatment. J Neurol Neurosurg Psychiatry 50:853–860
Nakamura T, Kanayama R, Sano R et al (1991) Quantitative analysis of ocular movements in Parkinson’s disease. Acta Otolaryngol 481(Suppl):559–562
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Marino, S., Lanzafame, P., Sessa, E. et al. The effect of l-Dopa administration on pursuit ocular movements in suspected Parkinson’s disease. Neurol Sci 31, 381–385 (2010). https://doi.org/10.1007/s10072-009-0180-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-009-0180-1