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Candidate genes for temporal lobe epilepsy: a replication study

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Abstract

The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1β (IL-1β), interleukin 1β (IL-1α), interleukin 1RA (IL-1RA), apolipoprotein E (ApoE) and prodynorphin (PDYN). We used a case-control approach comparing several polymorphisms within these candidate genes between unrelated TLE patients and matched controls. We were thus able to confirm the role of ApoE, IL-1α and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1β and PDYN. This failure should be interpreted with caution, as this may be due to the small size of our study groups and the resultant lack of statistical power.

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Authors and Affiliations

  1. Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland

    Annick Salzmann, Carmen Lambercy & Alain Malafosse

  2. Epilepsy Laboratory, University Hospital of Montpellier, Montpellier, France

    Arielle Crespel

  3. Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland

    Nader Perroud & Alain Malafosse

Authors
  1. Annick Salzmann
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  2. Nader Perroud
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  3. Arielle Crespel
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  4. Carmen Lambercy
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  5. Alain Malafosse
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Correspondence to Alain Malafosse.

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Salzmann, A., Perroud, N., Crespel, A. et al. Candidate genes for temporal lobe epilepsy: a replication study. Neurol Sci 29, 397–403 (2008). https://doi.org/10.1007/s10072-008-1060-9

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  • DOI: https://doi.org/10.1007/s10072-008-1060-9

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