Abstract
Cerebral amyloid angiopathy (CAA) is defined by the accumulation of amyloid in the walls of small-and medium-sized cerebral arteries. One of the most recognized complications of CAA is spontaneous, often recurrent, intracerebral hemorrhage, usually involving the cortex and/or subcortical white matter (“lobar hemorrhage”). Several useful animal and in vitro models as well as specific neuroimaging techniques have been recently developed, which are expected to provide detailed insight into the pathogenesis of CAA and contribute to the development of targeted antiamyloid therapies.
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References
Westermark P, Benson MD, Buxbaum JN et al (2007) A primer of amyloid nomenclature. Amyloid 14:179–183
Knudsen KA, Rosand J, Karluk D, Greenberg SM (2001) Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston Criteria. Neurology 56:537–539
Johnson KA, Gregas M, Becker JA et al (2007) Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 62:229–234
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Pezzini, A., Padovani, A. Cerebral amyloid angiopathy-related hemorrhages. Neurol Sci 29 (Suppl 2), 260–263 (2008). https://doi.org/10.1007/s10072-008-0957-7
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DOI: https://doi.org/10.1007/s10072-008-0957-7