Abstract
Sympathetic neural factors exert a key role in homeostatic blood pressure control. Evidence is available that abnormalities in sympathetic function may favour the development and progression of the hypertensive state. This paper will review the data collected throughout the years on the role of adrenergic mechanisms in the pathophysiology of the hypertensive state. It will then examine the mechanisms and the consequences of the sympathetic overdrive reported in hypertension, with particular emphasis on its role in the development of target organ damage. Finally the therapeutic implications of hypertension-related neurogenic abnormalities will be highlighted.
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References
Kuchel O, Genest J (1997) A neurogenic origin of mild highrenin essential hypertension? N Engl J Med 297:222
Julius S, Krause L, Schork NJ et al (1991) Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens 9:77–84
Goldstein DS (1983) Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5:86–99
Grassi G, Cattaneo BM, Seravalle G (1998) Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension 31:68–72
Esler M, Lambert G, Jennings G (1989) Regional norepinephrine turnover in human hypertension. Clin Exp Hypertens A 11[Suppl 1]:75–89
Grassi G, Mancia G (2007) Hyperadrenergic and labile hypertension. In: Lip GH, Hall J (eds) Comprehensive hypertension. Mosby Elsevier, Philadelphia, pp 719–726
Grassi G, Seravalle G, Dell’Oro R et al (2000) Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension 36:538–542
Grassi G, Seravalle G, Quarti-Trevano F et al (2003) Effects of hypertension and obesity on the sympathetic activation of heart failure patients. Hypertension 42:873–877
Grassi G, Dell’Oro R, Quarti-Trevano F et al (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48:1359–1365
Grassi G, Seravalle G, Turri C, Mancia G (1999) Sympathetic nerve traffic responses to surgical removal of pheochromocytoma. Hypertension 34:461–465
Grassi G (2001) Renin-angiotensin-sympathetic crosstalks in hypertension: reappraising the relevance of peripheral interactions. J Hypertens 19:1713–1716
Grassi G, Cattaneo BM, Seravalle G et al (1997) Effects of chronic ACE inhibition on sympathetic nerve traffic and baroreflex control of circulation in heart failure. Circulation 96:1173–1179
Grassi G (2004) Counteracting the sympathetic nervous system in essential hypertension. Curr Opin Nephrol Hypertens 13:513–519
Grassi G, Quarti-Trevano F (2007) Blood pressure control and therapeutic modulation of the adrenergic overdrive. Curr Hypertens Rep 9:167–169
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Grassi, G., Quarti-Trevano, F., Dell’Oro, R. et al. Essential hypertension and the sympathetic nervous system. Neurol Sci 29 (Suppl 1), 33–36 (2008). https://doi.org/10.1007/s10072-008-0882-9
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DOI: https://doi.org/10.1007/s10072-008-0882-9