Abstract.
We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson’s disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81–4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.
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Zappia, M., Annesi, G., Nicoletti, G. et al. Association of tau gene polymorphism with Parkinson’s disease. Neurol Sci 24, 223–224 (2003). https://doi.org/10.1007/s10072-003-0141-z
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DOI: https://doi.org/10.1007/s10072-003-0141-z