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Pear pomace water extract suppresses hepatic lipid peroxidation and protects against liver damage in rats fed a high fat/cholesterol diet

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Abstract

The protective effect of pear pomace water extract (PPWE) against hepatic lipid peroxidation was investigated in rats fed a 41% kcal fat diet containing 0.21% cholesterol (HFCD). For 5 weeks, 200 or 400 mg/kg of PPWE was administrated once daily via oral gavage. Body weights were lower in the PPWE-treated group than in the control group. Serum total antioxidant capacity increased, whereas hepatic thiobarbituric acid reactive substances significantly decreased after the administration of PPWE. PPWE recovered the HFCD-induced reduction of hepatic glutathione S-transferase and glutathione peroxidase activity. The serum alanine aminotransferase and aspartate aminotransferase activities significantly decreased on PPWE treatment. The present investigation suggests that PPWE represents a valuable natural antioxidant source for use in the health food industry.

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Acknowledgements

This research was supported by the Bio-industry Technology Development Program by the, Ministry of Agriculture, Food and Rural Affairs (313019-03-3-HD030). The authors would like to thank Enaga (www.enago.co.kr) for the English language review.

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  1. Department of Food and Nutrition, Mokpo National University, Muan, Jeonnam, 58554, Korea

    Mi-Kyoung You, Jin Rhuy & Hyeon-A Kim

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  1. Mi-Kyoung You
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  2. Jin Rhuy
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Correspondence to Hyeon-A Kim.

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You, MK., Rhuy, J. & Kim, HA. Pear pomace water extract suppresses hepatic lipid peroxidation and protects against liver damage in rats fed a high fat/cholesterol diet. Food Sci Biotechnol 26, 801–806 (2017). https://doi.org/10.1007/s10068-017-0084-4

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  • DOI: https://doi.org/10.1007/s10068-017-0084-4

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