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Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts

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Abstract

Cirsium setidens Nakai contains bioactive compounds that exert biological activities. Method validation for analysis of the pectolinarin content in Cirsium setidens extracts (CSE) and radical scavenging-linked antiobesity activities using 3T3-L1 cells and C57BL/6 mice were performed. The pectolinarin content of CSE was 2.81±0.01 mg/g with a high degree of linearity in calibration curves (R 2=0.9999). CSE exhibited free radical-scavenging activities and a reducing power. CSE and pectolinarin inhibited lipid accumulation during adipogenesis of 3T3-L1 cells via down-regulation of adipogenic transcription factors. CSE supplementation suppressed body weight in C57BL/6 mice fed a high fat diet and reduced plasma total cholesterol, triglyceride, insulin, and glucose levels. Pectolinarin-enriched CSE can be considered as a good source of natural antioxidants and antiobesity ingredients.

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Authors and Affiliations

  1. Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, Gangwon, 24341, Korea

    Young-Jun Lee, Jin-Ha Lee, Young-Hyun Kim, Jae-Hwan Kim, Seok-Yeong Yu, Dan-Bi Kim, Jong Seok Lee, Myoung Lae Cho & Ok-Hwan Lee

  2. Hurum Central Research Institute, Cheongwon, Chungbuk, 28116, Korea

    Ju-Hyun Cho & Bong Kyun Kim

  3. Department of Food Science and Biotechnology, CHA University, Seongnam, 11160, Korea

    Boo-Yong Lee

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  1. Young-Jun Lee
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  2. Jin-Ha Lee
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Correspondence to Ok-Hwan Lee.

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Lee, YJ., Lee, JH., Kim, YH. et al. Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts. Food Sci Biotechnol 24, 2235–2243 (2015). https://doi.org/10.1007/s10068-015-0298-2

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  • DOI: https://doi.org/10.1007/s10068-015-0298-2

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